Correlates of protection for enteric vaccines

Vaccine
J HolmgrenMitra Saadatian-Elahi

Abstract

An immunological Correlate of Protection (CoP) is an immune response that is statistically interrelated with protection. Identification of CoPs for enteric vaccines would help design studies to improve vaccine performance of licensed vaccines in low income settings, and would facilitate the testing of future vaccines in development that might be more affordable. CoPs are lacking today for most existing and investigational enteric vaccines. In order to share the latest information on CoPs for enteric vaccines and to discuss novel approaches to correlate mucosal immune responses in humans with protection, the Foundation Mérieux organized an international conference of experts where potential CoPs for vaccines were examined using case-studies for both bacterial and viral enteric pathogens. Experts on the panel concluded that to date, all established enteric vaccine CoPs, such as those for hepatitis A, Vi typhoid and poliovirus vaccines, are based on serological immune responses even though these may poorly reflect the relevant gut immune responses or predict protective efficacy. Known CoPs for cholera, norovirus and rotavirus could be considered as acceptable for comparisons of similarly composed vaccines while more work is still ...Continue Reading

Citations

Mar 26, 2019·Journal of American College Health : J of ACH·Kayla SandlerKristen A Feemster
Jul 10, 2019·Human Vaccines & Immunotherapeutics·Esther Ndungo, Marcela F Pasetti
Aug 9, 2019·The American Journal of Tropical Medicine and Hygiene·James T GaensbauerMario A Melgar
Jul 30, 2020·Journal of Leukocyte Biology·Tertuliano Alves Pereira NetoHelton da Costa Santiago
Nov 8, 2016·Human Vaccines & Immunotherapeutics·Manjari Lal, Courtney Jarrahian
Feb 24, 2021·Network Modeling and Analysis in Health Informatics and Bioinformatics·Fariya Khan, Ajay Kumar
Apr 4, 2021·Vaccines·Till KochChristine Dahlke
Jul 3, 2021·Microorganisms·Richard WalkerLouis Bourgeois
Jul 6, 2021·Virus Research·Sarah CaddyUlrich Desselberger
Jul 28, 2021·Nature Reviews. Immunology·Ed C Lavelle, Ross W Ward
Nov 7, 2021·Scientific Reports·Benjamin LeeBeth D Kirkpatrick
Oct 21, 2021·The Journal of Infectious Diseases·Anita S Iyer, Jason B Harris

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