Correlates of protection induced by live Aro- Salmonella typhimurium vaccines in the murine typhoid model

Immunology
J A HarrisonC E Hormaeche

Abstract

Live attenuated salmonella vaccines generally confer better protection than killed vaccines. The immune responses in BALB/c mice elicited by immunization with a live attenuated Aro Salmonella typhimurium vaccine given orally, intravenously or subcutaneously were compared with those elicited by killed whole-cell vaccines (acetone or heat-treated) given subcutaneously. Live vaccines given by all routes elicited higher interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) responses in spleen cells against an alkali-treated whole-cell salmonella lysate than did killed vaccines. Live and killed vaccines elicited high total antibody levels to smooth lipopolysaccharide (LPS) (enzyme-linked immunosorbent assay), but all live vaccine regimes elicited higher IgG2a, suggesting a Th1 response. Oral and intravenous vaccination with live organisms elicited IgA against smooth LPS which subcutaneous vaccination with live or killed salmonellae failed to evoke. Western blots using rough whole-cell lysates showed that all vaccines elicited a varied anti-protein response; however, all groups immunized with live organisms recognized three unidentified bands of MW 52,000, 46,000 and 18,000 which were consistently absent in groups immunized with kill...Continue Reading

References

Mar 1, 1991·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·T Segall, A A Lindberg
Feb 1, 1991·Microbial Pathogenesis·C E HormaecheB A Stocker
Oct 1, 1990·Microbial Pathogenesis·G L CooperC E Hormaeche
May 1, 1989·Reviews of Infectious Diseases·M M LevineR Germanier
Jun 1, 1989·Microbial Pathogenesis·A Brown, C E Hormaeche
Apr 1, 1988·Microbial Pathogenesis·R Demarco de HormaecheK Senior
Mar 1, 1982·The Journal of Experimental Medicine·P C IsaksonP H Krammer
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann

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Citations

Sep 4, 2008·Infection and Immunity·Douglas M HeithoffMichael J Mahan
Oct 13, 2001·Infection and Immunity·D M HeithoffM J Mahan
May 25, 2011·The Journal of General and Applied Microbiology·Won Suck YoonYong Keun Park
Aug 22, 2000·American Journal of Veterinary Research·H AgersøJ P Nielsen
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claudia RollenhagenDirk Bumann
May 26, 2005·Journal of Immunological Methods·Deborah AshbyD William Cameron
Apr 23, 2015·Vaccine·Sharon M Tennant, Myron M Levine
Mar 13, 2001·The Veterinary Journal·P MastroeniG Dougan
Oct 13, 1999·FEMS Immunology and Medical Microbiology·M L Kim, J M Slauch
Sep 19, 2014·PLoS Pathogens·Chris CowardPietro Mastroeni
May 16, 2003·Journal of Medical Microbiology·Pietro Mastroeni, Nathalie Ménager

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