Correlating coating characteristics with the performance of drug-coated balloons--a comparative in vitro investigation of own established hydrogel- and ionic liquid-based coating matrices

PloS One
Sebastian KauleSvea Petersen

Abstract

Drug-coated balloons (DCB), which have emerged as a therapeutic alternative to drug-eluting stents in percutaneous cardiovascular intervention, are well described with regard to clinical efficacy and safety within a number of clinical studies. In vitro studies elucidating the correlation between coating additive and DCB performance are however rare but considered important for the understanding of DCB requirements and the improvement of established DCB. In this regard, we examined three different DCB-systems, which were developed in former studies based on the ionic liquid cetylpyridinium salicylate, the body-own hydrogel hyaluronic acid and the pharmaceutically well-established hydrogel polyvinylpyrrolidone, considering coating morphology, coating thickness, drug-loss, drug-transfer to the vessel wall, residual drug-concentration on the balloon surface and entire drug-load during simulated use in an in vitro vessel model. Moreover, we investigated particle release of the different DCB during simulated use and determined the influence of the three coatings on the mechanical behavior of the balloon catheter. We could show that coating characteristics can be indeed correlated with the performance of DCB. For instance, paclitaxel ...Continue Reading

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Citations

Sep 1, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wiebke KempinAnne Seidlitz
Jan 27, 2017·Chemical Reviews·Ksenia S EgorovaValentine P Ananikov
Mar 3, 2018·Cardiovascular Engineering and Technology·Emily A TurnerSaami K Yazdani
Jan 23, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kirby FuglsbySujan Lamichhane
Aug 15, 2018·Frontiers in Pharmacology·Emily TurnerSaami K Yazdani
Jul 8, 2016·Cardiology and Therapy·Rasmus Kapalu Broge RichelsenSvend Eggert Jensen
Dec 23, 2019·Journal of Vascular Surgery·Eric Ducasse, Caroline Caradu

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Methods Mentioned

BETA
confocal microscopy
force measurements
electron microscopy

Software Mentioned

SPSS

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