Correlating efficacy and immunogenicity in malaria vaccine trials

Seminars in Immunology
Matthew B B McCallBenjamin Mordmüller

Abstract

The availability of an effective and appropriately implemented malaria vaccine would form a crucial cornerstone of public health efforts to fight this disease. Despite many decades of research, however, no malaria vaccine has yet shown satisfactory protective efficacy or been rolled-out. Validated immunological substitute endpoints have the potential to accelerate clinical vaccine development by reducing the required complexity, size, duration and cost of clinical trials. Besides facilitating clinical development of existing vaccine candidates, understanding immunological mechanisms of protection may drive the development of fundamentally new vaccination approaches. In this review we focus on correlates of protection in malaria vaccine development: Does immunogenicity predict malaria vaccine efficacy and why is this question particularly difficult? Have immunological correlates accelerated malaria vaccine development in the past and will they facilitate it in the future? Does Controlled Human Malaria Infection represent a valid model for identifying such immunological correlates, or a correlate of protection against naturally-acquired malaria in itself?

Citations

Jan 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin MordmüllerMorten A Nielsen
Aug 30, 2019·Nature Reviews. Immunology·Jean-Philippe Julien, Hedda Wardemann
Mar 17, 2020·Frontiers in Immunology·Catherine J Mitran, Stephanie K Yanow
Jul 16, 2020·Vaccines·Mariusz SkwarczynskiWaleed M Hussein
Jan 28, 2021·Expert Review of Vaccines·Danielle I Stanisic, Matthew B B McCall
Apr 6, 2021·Frontiers in Immunology·Carlos Lamsfus CalleBenjamin Mordmüller
Jan 11, 2022·The Journal of Experimental Medicine·Ilka Wahl, Hedda Wardemann

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