Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer

Oncotarget
Hongchao ZhenQin Li

Abstract

Molecular subtypes and Nottingham Prognostic Index (NPI) are both prognostic models for breast cancer patients. We evaluated the association between molecular subtypes and NPI in 1042 breast cancer patients. The molecular subtypes indicating poorer prognosis were positively correlated to higher NPI (r = 0.138, P = 0.001). ER positive expression and PR high expression were positively correlated with NPI (r = 0.142, P = 0.001; r = 0.139, P = 0.001; respectively) and negatively correlated with histological grade (r = -0.233, P < 0.001; r = -0.176, P < 0.001; respectively). Ki67 status was negatively correlated with NPI and positively correlated with histological grade (r = -0.120, P =0.004; r = 0.197, P < 0.001; respectively). The percentages of cases with NPI score 2.00-3.40 were higher in the luminar A, ER+, PR high expression and Ki67 low expression group, and the percentages of cases with NPI > 5.40 were higher in the HER2 overexpression subtype, basal-like subtype, ER-, PR low/negative expression, and Ki67 high expression groups. The excellent consistence was observed between histological grade and molecular subtypes, ER, PR, Ki67. The difference of histological grade between the HER2 positive and negative group was statistic...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·M H GaleaI O Ellis
Sep 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ContessoJ Rouesse
Oct 1, 1987·British Journal of Cancer·J H ToddJ L Haybittle
Oct 2, 2003·British Journal of Cancer·P CholletF Penault-Llorca
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maggie C U CheangTorsten O Nielsen
Jun 11, 2008·Breast Cancer Research and Treatment·Rebecca DentSteven A Narod
Jul 25, 2009·The Breast : Official Journal of the European Society of Mastology·Laure VoguetGilles Body
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K David VoducHagen Kennecke
Dec 8, 2011·Breast Cancer Research and Treatment·Aoife J LoweryKarl J Sweeney
Sep 8, 2012·Biologics : Targets & Therapy·Chad J Creighton
Aug 1, 2013·Breast Cancer Research and Treatment·M J EngstrømA M Bofin
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Sep 4, 2013·Breast Care·Nadia HarbeckMichael Gnant
Oct 2, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A García FernándezN Giménez
Jan 13, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F FeiH Bonnefoi
Oct 3, 2015·The Breast : Official Journal of the European Society of Mastology·R H T KoornstraS C Linn
Nov 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J EpsteinPeter W Groeneveld
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tari A KingClifford A Hudis
Apr 27, 2016·Breast Cancer Research and Treatment·Andrew R GreenI O Ellis
May 12, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Mahshid GhonchehHamid Salehiniya
Mar 10, 2017·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·D P JoyceM J Kerin

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.