Correlation analysis for the incubation period of prion disease.

Prion
Se-Eun BaeHyeon S Son

Abstract

Previous studies have shown that genetic quantitative trait loci (QTL), strain barriers, inoculation dose and inoculation method modulate the incubation period of prion diseases. We examined the relationship between a diverse set of physical, genetic and immunological characteristics and the incubation period of prion disease using correlation analyses. We found that incubation period was highly correlated with brain weight. In addition, mean corpuscular volume and cell size were strongly correlated with incubation period, indicating that the physical magnitude of prion-infected organs or individual cells may be important in determining the incubation period. Given the same prion inoculation dose, animals with a lower brain weight, mean corpuscular volume or cell size may experience more virulent disease, as the effective concentration of abnormal prion, which might regulate the attachment rate of prions to aggregates, is increased with smaller capacity of brains and cells. This is partly consistent with previous theoretical modeling. The strong correlations between incubation period and physical properties of the brain and cells in this study suggest that the mechanism underlying prion disease pathology may be physical, indica...Continue Reading

References

Feb 1, 1977·The Journal of General Virology·R H Kimberlin, C Walker
Nov 12, 1976·Science·T Allison, D V Cicchetti
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G A CarlsonS B Prusiner
Aug 15, 1986·Cell·G A CarlsonS B Prusiner
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M PanF E Cohen
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·G C TellingS B Prusiner
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J AllmanA Hakeem
Aug 29, 1996·Nature·R M AndersonG A Wells
Jan 1, 1996·Folding & Design·Z HuangF E Cohen
Nov 26, 1997·Journal of Virology·M R ScottS B Prusiner
Apr 29, 1999·Biochemistry·H LiuT L James
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R ScottS B Prusiner
Oct 3, 2000·Genomics·D A StephensonG A Carlson
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R McLean, C J Bostock
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·S E LloydE M Fisher
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·K ManolakouI J Jackson
Mar 29, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jules Hernández-SánchezJohn L Williams
Jul 3, 2002·Epidemiology·Jérôme N Huillard d'AignauxAnnick Alpérovitch
Jul 30, 2003·Biophysical Journal·R V KulkarniF Pázmándi
Jul 21, 2006·Neurology·Paul BrownTakeshi Sato
Oct 20, 2009·Cell Stress & Chaperones·Ane Marcos-CarcavillaKatayoun Moazami-Goudarzi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.