Correlation analysis of laser Doppler flowmetry signals: a potential non-invasive tool to assess microcirculatory changes in diabetes mellitus

Medical & Biological Engineering & Computing
Cerine Lal, Sujatha Narayanan Unni

Abstract

Measurement and analysis of microcirculation is vital in assessing local and systemic tissue health. Changes in microvascular perfusion if detected can provide information on the development of various related diseases. Laser Doppler blood flowmetry (LDF) provides a non-invasive real-time measurement of cutaneous blood perfusion. LDF signals possess fractal nature that represents the correlation in the successive signal elements. Changes in the correlation of flow and its associated parameters could be used as a tool in differentiating the ailments at different stages or assessing the treatment effectiveness of a particular ailment. Spectral domain analysis of LDF signals reveals five characteristic frequency peaks corresponding to local and central regulatory mechanisms of the human body, namely metabolic, neurogenic, myogenic, respiration, and heart rate. This paper investigates the changes in the fractal nature and constituent frequency bands of laser Doppler signals in diabetic and healthy control subjects acquired from the glabrous skin of the foot so as to provide an assessment of microcirculatory dynamics. As a pilot study, it was attempted on a set of healthy control and diabetic volunteers, and the obtained results ind...Continue Reading

References

May 1, 1991·Journal of Biomedical Engineering·M D BarnesR Mani
Jun 1, 1991·Journal of Applied Physiology·R W GlennyJ B Bassingthwaighte
Dec 1, 1983·Journal of the Royal Society of Medicine·J D WardG Knight
Jan 1, 1993·Medical & Biological Engineering & Computing·A N Obeid
Mar 1, 1993·Journal of Biomedical Engineering·P ZiouposS MacRury
Mar 1, 1996·Journal of the American College of Cardiology·S B WilliamsM A Creager
Feb 1, 1996·Diabetes Research and Clinical Practice·J E Tooke
Sep 18, 1998·Bulletin of Mathematical Biology·M Bracic, A Stefanovska
Oct 8, 1999·IEEE Transactions on Bio-medical Engineering·A StefanovskaH D Kvernmo
Mar 18, 2000·Pflügers Archiv : European journal of physiology·A EkeC Ikrényi
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·I M Braverman
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Mar 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ary L GoldbergerH Eugene Stanley
Mar 6, 2002·Physiological Measurement·A EkeL R Kozak
Mar 14, 2002·Medical Engineering & Physics·G Carolan-ReesT M Griffith
Apr 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Torbjörn SöderströmHenry Svensson
May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·J D RojasR Martínez-Zaguilán
Sep 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Lynn A SokolnickiNisha Charkoudian
Oct 23, 2008·Cell and Tissue Research·Wineke BakkerVictor W M van Hinsbergh
Feb 3, 2009·Vascular Health and Risk Management·Majid Kalani
Apr 17, 2010·Physics Reports·Y ShiogaiP V E McClintock
Jul 15, 1997·Physica a·Michael J CannonJames B Bassingthwaighte
Mar 26, 2013·Diabetes Research and Clinical Practice·Leonor Guariguata

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Citations

Apr 16, 2019·Journal of Biophotonics·Krishnapriya VenugopalUte Lindauer
May 31, 2018·Cardiovascular Drugs and Therapy·Qinzhong Chen, Robert S Rosenson
Jun 28, 2016·Vestnik oftalmologii·T N SafonovaN P Kintukhina

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