Correlation and expression of p53, HER-2, vascular endothelial growth factor (VEGF), and e-cadherin in a high-risk breast-cancer population

International Journal of Clinical Oncology
Eugene M HowardRuby Kochhar

Abstract

Many genetic traits common to aggressive breast carcinoma have been identified; yet little is known about the interrelationships of such traits during tumor development, especially in women prone to aggressive cancer. This study examined the expression of four biological markers associated with poor prognosis at each stage of breast cancer progression in primary tumors from women of lower economic status and assessed the relationship between these markers. Archived primary breast tumors from 77 patients were assessed by immunohistochemical analysis for expression of human epidermal growth receptor 2 (HER-2), p53, vascular endothelial growth factor (VEGF), and e-cadherin, and the relationships between the expressions of these molecules were studied. Twenty-two (29%) patients had advanced (stage III or IV) disease. HER-2, VEGF, e-cadherin, and p53 signal were positive for 31 (40%), 58 (75%), 63 (82%), and 37 (48%) of patients, respectively. Among the markers tested, only p53 exhibited a significant association between expression and stage of the disease ( P = 0.012). Expression of e-cadherin was positively associated with HER-2 overexpression ( P = 0.004), and high levels of HER-2 occurred with strongly positive e-cadherin tumors...Continue Reading

Citations

Oct 2, 2004·Journal of Cancer Research and Clinical Oncology·Eugene M HowardRuby Kochhar
Mar 4, 2006·BMC Cancer·José Roberto F CaldeiraSilvia R Rogatto
Jan 15, 2009·Folia Histochemica Et Cytobiologica·Anil Kumar AgrawalEwa Nienartowicz
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Gulisa TurashviliZdenek Kolár
Jul 16, 2020·Breast Cancer Research : BCR·Claire BonneauFatima Mechta-Grigoriou
Jul 3, 2010·The Journal of Biological Chemistry·Emhonta JohnsonRuth A Keri

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