Correlation and prognostic significance of serum amylase, serum lipase, and plasma cholinesterase in acute organophosphorus poisoning

Journal of Family Medicine and Primary Care
Ajit DungdungMd K Saba

Abstract

Organophosphorus (OP) are substances that are originally produced by the reaction of alcohols and phosphoric acid. These OP compounds are the main components of herbicides, pesticides, and insecticides. These are easily available in developing country like India; there is lack of awareness about these chemicals which results in high morbidity and mortality. To estimate levels of amylase, lipase, plasma cholinesterase in acute OP poisoning. To assess severity of OP poisoning by using plasma cholinesterase levels and correlating it with other two markers. Predicting the severity of acute OP poisoning by using these biochemical markers. A hospital-based observational study was conducted on 100 subjects who were clinically diagnosed of acute OP poisoning. Subjects of either gender of all age-groups were included in the study. On admission, plasma cholinesterase, serum amylase, and serum lipase were measured. Based on plasma cholinesterase activity at the time of admission, subjects were divided into three groups. Group I-having 20-50% of plasma cholinesterase activity; Group II-10-20% of plasma cholinesterase activity; and Group III <10% of plasma cholinesterase activity. Among 100 patients it was seen that serum amylase and serum ...Continue Reading

References

Dec 29, 1998·Journal of Toxicology. Clinical Toxicology·W C LeeS D Lee
Oct 7, 2004·Renal Failure·Chun-Liang LinChiu-Ching Huang
Aug 21, 2007·Human & Experimental Toxicology·Surjit SinghKirandip Gill
Sep 21, 2010·The Journal of Emergency Medicine·Sahin AslanMustafa Uzkeser
Feb 8, 2020·Journal of Applied Toxicology : JAT·Ning DongJihong Xing

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