PMID: 9426689Jan 14, 1998Paper

Correlation between 1p deletions and aneusomy in human colorectal adenomas

International Journal of Cancer. Journal International Du Cancer
A Di VinciW Giaretti

Abstract

Human sporadic colorectal adenomas are characterized by a relatively high occurrence of aneuploidy. Similarly, 1p deletions have been reported to be an early event in colorectal tumorigenesis, while chromosome 7, 17 and 18 gain/losses were also found. The present study investigated 1p deletions, the numerical aberrations of chromosomes 1, 7, 17 and 18, and the nuclear DNA content as obtained by flow cytometry in a series of 34 human sporadic colorectal adenomas. From these adenomas, 51 intra-adenoma regions were microdissected according to 2 degrees of dysplasia and presence of foci of early cancer. Isolated epithelial nuclei were analyzed by fluorescence in situ hybridization interphase cytogenetics using centromeric probes for chromosomes 7, 17 and 18 and, in a double-target analysis, a centromeric probe for chromosome 1 simultaneously with a telomeric probe mapping to the 1p36 band. Aneuploidy incidence due to presence of numerical aberrations for at least one among the investigated chromosomes and/or abnormal flow-cytometric DNA content was 35%, while 1p deletion incidence was 38%. The correlation of 1p deletions with aneuploidy was statistically highly significant (p = 0.003), suggesting that loss of genes in this region m...Continue Reading

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Citations

Oct 26, 2001·Postgraduate Medical Journal·L ShaoQ Huang
Jul 15, 2011·Clinical and Experimental Gastroenterology·Claire M PayneHarris Bernstein
Jan 26, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kyoung Ah KangJin Won Hyun
Aug 20, 2016·DNA and Cell Biology·Matías González-QuirozJaime Meléndez
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·T SugaiC Itoh
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christopher DouvilleRachel Karchin
May 3, 2002·The Journal of Molecular Diagnostics : JMD·Mahmoud Rezk Abd-Elwahed Hussein, Gary Stewart Wood

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