Correlation between apparent diffusion coefficient of magnetic resonance imaging and tumor-infiltrating lymphocytes in breast cancer

La Radiologia medica
Marco FoganteAndrea Giovagnoni

Abstract

To evaluate a possible correlation between apparent diffusion coefficient (ADC) value and tumor-infiltrating lymphocytes (TILs) level in breast cancer (BC). A second objective was to assess whether there were other histopathologic features that could affect mean ADC value. In this 4-year retrospective study were included 125 patients who underwent radical or modified mastectomy for monofocal BC. All subjects had performed preoperative MRI with the same 1.5-T machine and protocol, which consisted of STIR, DWI and DCE sequences. Based on TIL score, BCs were stratified into two groups: absent-low TIL (≤ 10%) and medium-high TIL (> 10%). The t test was used to correlate mean ADC value with TIL groups. Receiver operating characteristic curve and Youden index were used in order to identify ADC value threshold to distinguish the two TIL groups. BC patients with absent-low TIL level and medium-high TIL one were, respectively, 66 (52.8%) and 59 (47.2%). Mean ADC value was 1.05 ± 0.19 * 10-3 mm2 s-1. Absent-low TIL group showed a lower mean ADC value than medium-high TIL one (0.96 ± 0.18 * 10-3 mm2 s-1 vs 1.14 ± 0.16 * 10-3 mm2 s-1; p < 0.0001). ADC value threshold in order to distinguish the two TIL groups with maximum sensitivity (67.8...Continue Reading

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Citations

Oct 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Roberto García-FigueirasJoan C Vilanova
May 4, 2021·Clinical and Translational Radiation Oncology·Jarey H WangClifton David Fuller
Jun 3, 2021·International Journal of Environmental Research and Public Health·Vincenza GranataFrancesco Izzo
Aug 26, 2021·AJR. American Journal of Roentgenology·Hyo-Jae LeeHyo Soon Lim
Aug 29, 2021·Journal of Magnetic Resonance Imaging : JMRI·Tiantian BianXiaohui Su

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