PMID: 8599992Jan 1, 1996Paper

Correlation between argyrophilic nucleolar organizer region counts and labelling index in multiple myeloma

European Journal of Haematology
F MarmontL Resegotti

Abstract

The correlation between the bromodeoxiuridine (BrdU)-labelling index (LI) of plasma cells and a new proliferation marker, the Argyrophilic Nucleolar Organizer Regions (AgNORs), was investigated in 44 myeloma patients at diagnosis. A preliminary analysis was made to verify the reproducibility of the assessment of plasma cell infiltration (PC%) in bone marrow aspirates, used to collect cells for LI determination, and in bone marrow biopsies, used for AgNORs evaluation. Although an overall good correlation was observed between PC% in biopsies and aspirates (r=0.58, p=0.001), the ratio between PC% in biopsies and in aspirates ranged form 0.35 to 7.5. Only 17 patients (38.6%) were within the 0.5-1.5 range. A positive correlation between LI and AgNORs was observed in these patients (r=0.68, p=0.003), whereas the correlation was lost in patients with higher ratio between PC% in biopsies and in aspirates (r=0.08, p=0.69). The prognostic significance of AgNORs was confirmed by survival analysis, showing a reduced survival for patients with high (>4.4) AgNOR counts (14 months vs 35 months, p=0.004). The AgNORs analysis therefore allows the simultaneous evaluation of myeloma cell infiltration, degree of differentiation and kinetics of gro...Continue Reading

References

Dec 1, 1992·British Journal of Haematology·A PichR Navone
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·A PichR Navone
Sep 1, 1990·Journal of Clinical Pathology·E P Nikicicz, D H Norback
Feb 1, 1987·The Journal of Pathology·J Crocker, P Nar
Jan 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BoccadoroT Barbui
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Feb 1, 1994·Leukemia & Lymphoma·A PichF Marmont

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Citations

Mar 1, 1997·The American Journal of Surgical Pathology·A PichR Navone
Jul 27, 2000·Journal of Clinical Pathology·S I PapadhimitriouM Stamatelou
Aug 25, 1999·Cancer Genetics and Cytogenetics·W LeeK Han

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