Abstract
The quantification of argyrophilic nucleolar organizer regions (AgNOR) was performed in 34 cases of adenoid cystic carcinoma (ACC) to determine (1) whether AgNOR count correlates with its different histologic grades pertinent to prognosis, and (2) whether AgNOR counts can offer any additional prognostic advantage over histologic grading. According to Szanto et al.'s histologic grading criteria (4), 12 cases were Grade 1, 7 cases Grade 2, and 15 were Grade 3. Patients were divided into 20 favorable cases (without metastases) and 14 unfavorable cases (with metastases). Although most Grade 3 tumors had high AgNOR counts (> or = 4) and Grade 1 tumors with low (< 4) AgNOR counts outnumbered those with high AgNOR counts, considerable overlap of AgNOR values in different grades was observed. However, all unfavorable cases had high AgNOR counts regardless of their histologic grades, suggesting that the metabolic alterations associated with the malignancy level of ACC may partly be portrayed by the AgNOR count, irrespective of the histologic appearance. Cumulative survival rates of Grade 1 tumors and of tumors with low AgNOR counts were better than those of Grade 3 tumors and those with high AgNOR counts. Within the limited number of ca...Continue Reading
References
Apr 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·T M Tarpley, J S Giansanti
Jul 1, 1978·Cancer·K H PerzinA C Clairmont
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G P ChometteJ M Vaillant
Jul 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·W F van Heerden, E J Raubenheimer
Mar 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K HamperG Seifert
Jul 1, 1989·The Journal of Pathology·J CrockerM J Egan
Jul 1, 1989·The Journal of Pathology·M L CibullD Y Mason
Nov 1, 1989·The British Journal of Surgery·K MoranJ M Fitzpatrick
Apr 1, 1989·The Journal of Pathology·D D GiriJ C Underwood
Sep 15, 1984·Cancer·P A SzantoR A White
Jan 1, 1980·Chromosoma·D Hernandez-VerdunM Bouteille
Mar 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N YoshimiT J Slaga
May 1, 1994·Pathology International·E A VuhahulaH Ito
Jul 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M A KahnJ M Hermann-Petrin
Feb 1, 1993·The Journal of Pathology·I Fonseca, J Soares
Citations
Sep 12, 1998·Otolaryngologic Clinics of North America·S M KerpelP D Freedman
Dec 7, 2007·The American Journal of Surgical Pathology·Raja R SeethalaE Leon Barnes
Aug 4, 2004·Journal of Oral Science·Elena Riet Correa RiveroMaria Cassia Ferreira de Aguiar
Jul 1, 2010·Journal of Oral Science·Satyajitraje A TekadeKriti Bagri
Nov 17, 2009·Journal of the Indian Society of Pedodontics and Preventive Dentistry·S Mukhopadhyay
Aug 12, 2005·International Journal of Cancer. Journal International Du Cancer·Dai NakashimaHideki Tanzawa
Apr 27, 2016·Journal of International Society of Preventive & Community Dentistry·Sanjay MurgodSavita Jangal Krishnappa
Aug 27, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yaling TangYu Chen
Feb 7, 2007·Future Oncology·Marilena Vered, Dan Dayan
Apr 14, 2007·Virchows Archiv : an International Journal of Pathology·Mohammad Reza KeikhaeeTakashi Takata