Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma

British Journal of Cancer
C LinderS Linder

Abstract

We examined the localization of basic fibroblast growth factor (bFGF) in a series of human breast carcinomas using immunohistochemistry. Staining was observed in tumour cells in 15 out of 54 (28%) tumours and in the adjacent stroma in 34 out of 54 (63%) tumours examined. No correlation was observed between positive staining of these two compartments. The relationship between bFGF staining and expression of the metalloprotease stromelysin-3, and between bFGF and microvessel density, was examined. A statistically significant correlation (P < 0.003) was observed between bFGF staining of the stromal compartment and high expression of stromelysin-3 (ST-3; MMP-11) metalloprotease mRNA by stromal cells. In contrast, no correlation was observed between bFGF and intratumour microvessel density (IMD). These results raise the possibility that bFGF may be involved in the induction of stromelysin-3 mRNA expression in breast cancer stroma.

Citations

Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T TeesaluD Talarico
Mar 16, 2001·Breast Cancer Research : BCR·C DicksonV Fantl
Sep 4, 2008·International Journal of Cancer. Journal International Du Cancer·Sebastián GiulianelliClaudia Lanari
Feb 6, 2017·British Journal of Cancer·Annie RochetteAxel A Thomson
Mar 23, 2012·Breast Cancer Research and Treatment·Carole MassabeauAlain Fourquet
Sep 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher LieuScott Kopetz
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucie E JonesMark T Boyd

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