Correlation between BCG genomics and protective efficacy

Scandinavian Journal of Infectious Diseases
M A Behr

Abstract

Between the derivation of bacille Calmette-Guérin (BCG) vaccine in 1921 and the lyophilization of BCG daughter strains in the 1960s, a number of clinical trials were performed looking at the protective efficacy of BCG vaccination against tuberculosis. These trials differed from one another in a number of ways: they employed different methodologies for delivering the vaccine and interpreting outcomes; they were performed on populations with different genetic backgrounds and different levels of exposure to environmental Mycobacteria; and, finally, they used different BCG vaccine strains. The results of these trials were estimates of protective efficacy against pulmonary tuberculosis ranging from about 80% to nil. Because of the differences in outcomes and confounding variables, it is difficult to conclude whether differences in interventions alone may have contributed to the remarkably variable results. Analysis of BCG vaccines used in clinical trials suggests a trend towards decreasing efficacy with increased passage in the laboratory; however, trials that used relatively "older" BCG strains were generally performed at different sites than trials which used "younger" BCG strains. Genomic analysis of BCG vaccines demonstrates tha...Continue Reading

Associated Clinical Trials

References

Jan 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T F Brewer, G A Colditz
Sep 20, 1997·Nature·M A Behr, P M Small
Mar 6, 1999·Vaccine·M A Behr, P M Small
May 1, 1964·Diseases of the Chest·O L BETTAGD B RADNER
Jan 1, 1949·Tubercle·R G FERGUSON, A B SIMES

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Citations

Oct 15, 2005·Clinical Microbiology Reviews·T Mark Doherty, Peter Andersen
Jun 5, 2004·Annals of Clinical Microbiology and Antimicrobials·Mauricio Castañón-Arreola, Yolanda López-Vidal
Jul 18, 2009·Genetic Vaccines and Therapy·Larissa Lumi Watanabe IshikawaAlexandrina Sartori
Jan 15, 2011·Clinical & Developmental Immunology·Patricia L SempleStanley Ress
Jun 23, 2009·Tuberculosis·Nicole Ritz, Nigel Curtis
Feb 6, 2004·Expert Review of Vaccines·Anne S De Groot, Rino Rappuoli
Mar 31, 2005·American Journal of Infection Control·Hamdan Al-JahdaliDick Menzies
Sep 21, 2017·Expert Opinion on Biological Therapy·Roberto Zenteno-Cuevas
Jul 14, 2005·Nature Reviews. Microbiology·Peter Andersen, T Mark Doherty
Oct 18, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Serge Mostowy, Marcel A Behr
Apr 18, 2008·Scandinavian Journal of Infectious Diseases·Harald FjällbrantLars Olof Larsson
Jun 19, 2019·Current Pharmaceutical Biotechnology·Jyoti YadavRanjana Jaiwal
May 1, 2002·Current Opinion in Pulmonary Medicine·T Mark Doherty, Peter Andersen
Mar 29, 2003·Neuropathology and Applied Neurobiology·G G KovacsH Budka
Oct 21, 2016·Microbiology Spectrum·Timothy Lahey, C Fordham von Reyn

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