Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors

Human Pathology
Hiroshi MatonoM Tsuneyoshi

Abstract

Desmoid tumors (desmoid-type fibromatoses) are locally aggressive soft tissue tumors associated with the Wnt/beta-catenin signaling pathway (APC-beta-catenin-Tcf pathway). Matrix metalloproteinase-7, which is one of the target genes of the Wnt/beta-catenin signaling pathway, has been reported to play an important role in tumor progression. We examined the immunohistochemical expression of beta-catenin and matrix metalloproteinase-7 in 72 samples (63 primary and 9 recurrent samples, 63 patients) of sporadic desmoid tumors without familial adenomatous polyposis, and the genetic alteration of the beta-catenin gene in 33 frozen materials (22 primary and 11 recurrent samples, 22 patients). We further examined messenger RNA expression of matrix metalloproteinase 7 by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and compared the results with those of normal skeletal muscles. Immunohistochemically, there was a statistically significant correlation between widespread nuclear expression of beta-catenin and overexpression of matrix metalloproteinase-7 (P < .01 in extra-abdominal desmoid, Fisher test). There were 7 missense point mutations in the 22 primary frozen samples (32%). In the beta-catenin mutated group, m...Continue Reading

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Citations

Nov 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shuichi KuriharaMasazumi Tsuneyoshi
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Cheryl M Coffin, Rita Alaggio
Jan 15, 2014·World Journal of Gastroenterology : WJG·Guo-Li GuShi-Lin Wang
Dec 22, 2015·Cancer Medicine·Shunsuke HamadaYoshihiro Nishida
Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Woo Chul ChungYun Kyung Lee
Jun 6, 2019·Frontiers in Oncology·Milea J M TimbergenErik A C Wiemer
Sep 20, 2011·Journal of Agricultural and Food Chemistry·Meng-Chiu LinFeng-Yao Tang
Jan 21, 2020·Bulletin du cancer·Sébastien Salas, Frédéric Chibon
Jul 3, 2010·The American Journal of Pathology·Robert ForonjyJeanine D'Armiento

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