Correlation between blood group phenotype and virulence properties of Escherichia coli in patients with chronic urinary tract infection

International Journal of Antimicrobial Agents
T ZieglerR Fünfstück

Abstract

A predisposition to urinary tract infection (UTI) is associated with the expression of P1 as well as the presence of ABO blood group antigen on the boundary layer and with the secretor state. Infectious microorganisms interfere with specific molecules on epithelial cells, these are antigens of the P and ABO blood group system. The blood group phenotype was examined in 53 women (age 42 +/- 12 years) with chronic non-obstructive UTI. The diagnosis was established on the basis of clinical history as well as clinical laboratory and radiological findings. The ABO phenotype and the P1 antigen were analysed by anti-A and anti-B as well as anti-P1 serum. The Lewis phenotyping was performed by incubating erythrocytes with anti-Le(a) and anti-Le(b) serum. In all patients, the blood group status were investigated. The proportion of persons with B-phenotype was 23% (the incidence of this feature in the German population is 14.5%). P1 antigen was found in 76% patients. In comparison with P1 antigen-negative individuals, P1 antigen-positive persons have a longer disease history and suffer more frequently from symptomatic events as well as destructive renal changes. The Le (a)-antigen was detected in 82% and the Le (b)-phenotype was observed ...Continue Reading

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Citations

Apr 11, 2001·International Journal of Antimicrobial Agents·R FünfstückJ Hacker
Jun 16, 2011·International Journal of General Medicine·Daniele MinardiGiovanni Muzzonigro
Jul 18, 2006·International Journal of Antimicrobial Agents·Reinhard FünfstückKurt G Naber
Aug 9, 2005·Clinical Biochemistry·Christian MurrHarald Schennach
Nov 23, 2006·Methods in Enzymology·Ola Blixt, Nahid Razi
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling
Jan 1, 2019·Transfusion·Linn StenfeltMartin L Olsson
May 15, 2008·The Annals of Pharmacotherapy·Shawn D Anderson, John G Gums
Jul 3, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David M P De OliveiraMartina L Sanderson-Smith
Sep 28, 2005·Medicina clínica·Angel José González-Ordóñez

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