Correlation between brachial artery flow-mediated dilation and endothelial microparticle levels for identifying endothelial dysfunction in children with Kawasaki disease

Pediatric Research
Yue-Yue DingWen-Hua Yan

Abstract

We investigated vascular endothelial dysfunction by sonographic features of flow-mediated dilation (FMD) and circulating endothelial microparticles (EMPs) in Kawasaki disease (KD). Twenty-eight patients with KD were prospectively grouped according to stage of disease: acute, subacute, and convalescent. In addition, 28 healthy children and 28 febrile children were selected as controls. And cases in the convalescent phase were divided into two subgroups: coronary artery lesion (CAL) and no coronary lesion (NCAL). CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs were measured by flow cytometry; FMD was obtained by sonography. There were significant differences in FMD among the five groups. When compared with healthy controls, there were significantly greater numbers of CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs and a higher proportion of CD62E(+) EMPs in KD patients. The proportions and numbers of CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs in KD patients were not statistically different than in febrile controls. There were no significant differences in FMD and EMPs between the CAL and NCAL subgroups. There were significantly negative correlations between the values of FMD and EMPs in the three phases of KD. The increased lev...Continue Reading

References

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Citations

Aug 8, 2015·Journal of the American Society of Nephrology : JASN·Uta Erdbrügger, Thu H Le
Jan 31, 2018·Journal of Movement Disorders·Maryam GhahremaniYong Jeong
Nov 16, 2019·Biomarkers in Medicine·Elise F NorthropJustin R Ryder
Mar 20, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Concetta IraceCiro Indolfi
Sep 6, 2020·Current Opinion in Nephrology and Hypertension·In O Sun, Soon Hyo Kwon
Aug 10, 2019·Frontiers in Pediatrics·Xiang WangHai Tao Lv
Sep 30, 2016·Cell Structure and Function·Seiji YamamotoMasakiyo Sasahara
Jan 11, 2020·Frontiers in Immunology·Erkan DemirkayaIvona Aksentijevich
Oct 20, 2020·Frontiers in Pediatrics·Rakesh Kumar PilaniaSurjit Singh
Mar 9, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Guiming YangHaitao Lv
May 6, 2021·Free Radical Biology & Medicine·Nan YangMing-Lin Liu
Jan 3, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Santhosh Kumar RouthuSurjit Singh
Jul 22, 2021·Pediatric Research·Panagiota MarkopoulouTania Siahanidou
Mar 18, 2020·Genes & Diseases·Kanika AroraSurjit Singh

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