Correlation between C-reactive Protein with Malondialdehyde in Systemic Lupus Erythematosus Patients

International Journal of Rheumatology
Nur AtikLaniyati Hamijoyo

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive patient's serum. We collected the patients' data who had CRP level from Hasan Sadikin lupus registry and analysed MDA levels from the serum sample. MDA levels were analyzed using an ELISA method. The data obtained were analyzed using the Pearson correlation and Eta correlation test. The study involved 78 data patients as subjects. It was found that the median of CRP and MDA was 0.85 mg/l and 153.10 ng/ml, respectively. These results indicate that the CRP levels in SLE patients are still within normal limits. Statistical analysis showed no correlation between CRP and MDA level (r = 0.2, P > 0.05). Additionally, the correlation between CRP and MDA with organ involvement, ...Continue Reading

References

Jan 22, 2002·Journal of Psychosomatic Research·Paul H Black, Lisa D Garbutt
Jan 2, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David SimarCorinne Caillaud
Oct 9, 2009·Autoimmunity·J Batuca, J Delgado Alves
Oct 31, 2009·Clinical and Experimental Dermatology·Q ZhangY Zheng
Oct 13, 2011·Arthritis Research & Therapy·Simanta Pathak, Chandra Mohan
Sep 12, 2013·International Journal of Sports Medicine·X-D WuY-Q Chen
Oct 9, 2013·Nature Reviews. Rheumatology·Andras Perl
Mar 19, 2014·Journal of Biomedical Science·Dilip ShahBishnuhari Paudyal
Jun 3, 2014·Lancet·Larissa LisnevskaiaDavid Isenberg
Nov 19, 2015·Frontiers in Immunology·Timothy A GottschalkMargaret L Hibbs
May 8, 2016·Free Radical Biology & Medicine·Lauren Diebold, Navdeep S Chandel
Jun 24, 2017·Current Opinion in Rheumatology·Yaima L LightfootMariana J Kaplan
Nov 11, 2017·Advances in Experimental Medicine and Biology·T L de JagerS S Du Plessis
Dec 13, 2017·Cancer Cell·Asmaa El-Kenawi, Brian Ruffell
Feb 24, 2019·World Journal of Pediatrics : WJP·Lu PanSi-Rui Yang
Dec 5, 2019·International Journal of Molecular Sciences·Shinwan KanyBorna Relja

❮ Previous
Next ❯

Citations

Sep 5, 2020·Journal of Inflammation Research·Winni MaharaniNur Atik

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
ELISA

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.