Correlation between central stromal demarcation line depth and changes in K values after corneal cross-linking (CXL)

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Niklas PircherGerald Schmidinger

Abstract

A stromal demarcation line (DL) after corneal cross-linking (CXL) has lately been suggested as a surrogate parameter for the success of CXL. The aim of this study was to investigate the correlation between depth of the central DL 1 month and the change in K values 12 months after CXL. Treatment-naive subjects with keratoconus were treated using an accelerated CXL protocol [A-CXL(9*10)]. Depth of the DL/relative depth of the DL (DL%) was measured using Visante OCT imaging 1 month postoperatively (OP). Kmax/K2.5 (preOP) and change in Kmax/K2.5 (preOP - 12 months postOP) were assessed using corneal tomography (Pentacam HR, Oculus GmBH). Forty eyes were treated following the A-CXL(9*10). The mean DL depth was 200 ± 99 μm (range 71 to 479)/mean DL% = 42.70 ± 20.00% (range 17-90). There was no statistically significant correlation between stromal depth of the DL and change in Kmax or K2.5, respectively (Spearman rho DL/∆Kmax - 0.14 and DL/∆K2.5 - 0.14). Between DL% and the changes in maximum K values or K2.5, no statistically significant correlation was found as well (Spearman rho DL%/∆Kmax - 0.10 and DL%/∆K2.5 - 0.19). Mean change in Kmax after 12 months was - 0.68 ± 2.26 diopters (D) (median - 0.35 D) and - 0.82 ± 1.6 D (median - 0...Continue Reading

References

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Jul 6, 2011·American Journal of Ophthalmology·Juha M Holopainen, Kari Krootila
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Jun 26, 2013·Journal of Cataract and Refractive Surgery·Gerald SchmidingerFranz Prager
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May 27, 2014·Journal of Cataract and Refractive Surgery·Mariko MitaMinoru Tomita
May 9, 2015·Journal of Cataract and Refractive Surgery·Niklas PircherGerald Schmidinger
May 27, 2015·American Journal of Ophthalmology·Rohit ShettyHarsha Nagaraja
Jul 4, 2015·Clinical & Experimental Ophthalmology·Alex Lap Ki NgArthur Ck Cheng
Dec 9, 2016·Journal of Refractive Surgery·Tobias EhmkeBeatrice E Frueh

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Citations

Nov 3, 2020·European Journal of Ophthalmology·Sandra HoyekJoelle Antoun
Feb 6, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Nikolaos DervenisMiltos Balidis

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Pentacam
Corneal Power Distribution Display

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