PMID: 1326057Sep 1, 1992Paper

Correlation between chemical suppression of natural killer cell activity in mice and susceptibility to cytomegalovirus: rationale for applying murine cytomegalovirus as a host resistance model and for interpreting immunotoxicity testing in terms of risk of disease

Journal of Toxicology and Environmental Health
M K SelgradeJ H Dean

Abstract

The purpose of this study was to determine the relationship between chemical suppression of natural killer (NK) cell activity in mice and chemical effects on susceptibility to murine cytomegalovirus (MCMV) infection. The goal was to provide a rational basis for applying MCMV as a host resistance model for immunotoxicity testing and to provide risk assessors some guidance in relating suppression of NK cell activity to enhanced risk of disease. Data from studies with eight chemicals administered in various doses and by various routes were evaluated, and a significant correlation was observed between chemical suppression of virus-augmented NK cell activity and increased mortality due to MCMV infection. In contrast, effects of the same chemical treatments on spontaneous NK cell activity (i.e., basal activity in uninfected mice) did not correlate with effects of these chemicals on mortality due to MCMV. Although chemicals that suppressed spontaneous NK cell activity enhanced infection, the converse was not always true--that is, increased susceptibility to infection and suppression of virus-augmented NK cell activity were observed on three occasions when spontaneous NK cell activity was unaffected. This latter phenomenon plus the fac...Continue Reading

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Citations

Dec 18, 2001·Journal of Applied Toxicology : JAT·F CondevauxJ Descotes
Jun 15, 2007·Critical Reviews in Food Science and Nutrition·Nils-Gunnar Ilbäck, Göran Friman
Sep 1, 1993·Journal of Toxicology and Environmental Health·M K SelgradeJ W Allis
Jul 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M BüttnerK Heinritzi
Apr 8, 2010·Journal of Gastroenterology and Hepatology·Shigeki BambaAkira Andoh
Aug 26, 2000·Drug and Chemical Toxicology·T L GuoK L White
Dec 2, 2005·Toxicology Letters·Waldemar WagnerJarosław Dastych
Jan 1, 1997·Photochemistry and Photobiology·P A SteerenbergF R de Gruijl
Aug 1, 1996·Photochemistry and Photobiology·J GarssenH van Loveren
Aug 29, 2012·Ground Water·Takuya MatsumotoPradeep K Aggarwal
Jun 1, 2004·Current Protocols in Toxicology·Michael I LusterRobert Luebke
Feb 2, 2016·Current Protocols in Toxicology·Jamie C DeWittVictor J Johnson
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D KeilS B Pruett

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