Correlation between clinical and pathological features of oral lichen planus: A retrospective observational study

Medicine
Paula Boñar-AlvarezJ M Suárez-Peñaranda

Abstract

Oral lichen planus (OLP) is a common, chronic, inflammatory disease of autoimmune origin. The aim of this study is to determine the correlation of the histopathological features with clinical aspects and variants of OLP.We have retrospectively studied a group of 59 adult patients with confirmed clinical and histopathological diagnosis of OLP from the Oral Pathology Unit of the University of Santiago de Compostela (Spain). Clinical parameters: age, gender, location of the lesions, clinical type, toxic habits, and concomitant treatments were evaluated. Histopathologically, the epithelial response (hyperplasia vs atrophy), presence of ulceration, degree of interface lesion and distribution, intensity, and composition of the inflammatory infiltrate were analyzed.Patients treated with several systemic drugs had more atrophic/erosive forms of OLP (P = .019). Plasma cells were found more commonly in cases showing deep inflammatory involvement of the connective subepithelial tissue than in those where inflammation was only superficially located (P <.001). Their presence was also associated with epithelial erosion-ulceration (P <.01).In conclusion, patients treated with several drugs had more atrophic/erosive forms of OLP and frequently...Continue Reading

References

Feb 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J V Bagán-SebastiánY Jiménez
Aug 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·S D VincentT P Williams
Aug 22, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Erik H van der MeijIsaäc van der Waal
Mar 8, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Martin H ThornhillPaula M Farthing
Sep 8, 2007·The British Journal of Oral & Maxillofacial Surgery·Crispian Scully, Marco Carrozzo
Apr 13, 2010·Medicina oral, patología oral y cirugía bucal·Eulàlia Torrente-CastellsCosme Gay-Escoda
May 12, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A Bermejo-FenollN Salazar-Sánchez
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R RoopashreeAbhilasha Shukla
Dec 23, 2014·TheScientificWorldJournal·Marinka Mravak-StipetićMagdalena Grce
Feb 7, 2015·Indian Journal of Dermatology·Venkatesh Vishwanath KamathKomali Yerlagudda
Apr 27, 2016·Head & Face Medicine·Dorina LauritanoMassimo Petruzzi
Jun 29, 2016·Archives of Dermatological Research·Mohammad S AlrashdanMichael McCullough
Jul 13, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yi-Shing Lisa ChengSusan Muller

❮ Previous
Next ❯

Citations

Aug 9, 2019·Dermatologic Therapy·Saygo Tomo, Luciana E Simonato
Feb 8, 2021·Archives of Oral Biology·Túlio Morandin FerrisseAndreia Bufalino
Nov 20, 2020·Pathogens·Evelyn F ZhongParish P Sedghizadeh
Oct 13, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mario Pérez-SayánsAndrés Blanco-Carrión

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Jin-He Zhang, Zeng-Tong Zhou
Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Siriporn ChattipakornNipon Chattipakorn
Journal of the European Academy of Dermatology and Venereology : JEADV
Pia López-JornetA Pons-Fuster
© 2022 Meta ULC. All rights reserved