Abstract
Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative correlation between NPY-LI and duration of the disease. Thus, the study found significant correlations between CSF NPY-LI and emotional symptoms and behavior in organic dementia.
Citations
Aug 25, 2007·Brain Structure & Function·Alvaro DuqueLaszlo Zaborszky
Nov 12, 2013·Neuropeptides·Eva BorbélyZsuzsanna Helyes
Dec 22, 2000·Neurobiology of Aging·J L Cummings
Dec 3, 1999·Brain Research Bulletin·S NagF Tang
Feb 24, 2001·Pharmacotherapy·C H Rojas-FernandezC MacKnight
Jul 16, 2014·Canadian Journal of Physiology and Pharmacology·Francesco AngelucciCarlo Caltagirone
Jan 24, 2012·Peptides·Ritesh J RanganiNishikant K Subhedar
Jan 28, 2006·International Journal of Geriatric Psychiatry·Karin Björkman BjörkelundEdith Andersson
Nov 5, 2005·Journal of Advanced Nursing·Eun-Hi Kong
Mar 27, 2015·The Journal of Nutrition, Health & Aging·I PedrósA Camins
Dec 21, 2014·Biochimica Et Biophysica Acta·Patrick OecklMarkus Otto
Jun 12, 2014·Frontiers in Neuroanatomy·Lydia Ouellet, Etienne de Villers-Sidani
Mar 22, 2014·PloS One·Justyna A DobrowolskaRandall J Bateman
May 26, 2015·Revue neurologique·I SibonC Pierrot-Deseilligny
Jan 18, 2017·Disease Models & Mechanisms·Dennis Y KimSabine P Cordes
Jul 25, 1997·American Journal of Medical Genetics·S FroelichL Lannfelt
Aug 29, 2019·Current Alzheimer Research·Carla PetrellaCinzia Severini
Dec 2, 2015·The Journal of Biological Chemistry·Brian SpencerEliezer Masliah
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé