PMID: 8939279Jan 1, 1996Paper

Correlation between clinical characteristics and cerebrospinal fluid neuropeptide Y levels in dementia of the Alzheimer type and frontotemporal dementia

Alzheimer Disease and Associated Disorders
L MinthonL Gustafson

Abstract

Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative correlation between NPY-LI and duration of the disease. Thus, the study found significant correlations between CSF NPY-LI and emotional symptoms and behavior in organic dementia.

Citations

Nov 12, 2013·Neuropeptides·Eva BorbélyZsuzsanna Helyes
Jul 16, 2014·Canadian Journal of Physiology and Pharmacology·Francesco AngelucciCarlo Caltagirone
Jan 28, 2006·International Journal of Geriatric Psychiatry·Karin Björkman BjörkelundEdith Andersson
Nov 5, 2005·Journal of Advanced Nursing·Eun-Hi Kong
Mar 27, 2015·The Journal of Nutrition, Health & Aging·I PedrósA Camins
May 26, 2015·Revue neurologique·I SibonC Pierrot-Deseilligny
Jul 25, 1997·American Journal of Medical Genetics·S FroelichL Lannfelt
Aug 29, 2019·Current Alzheimer Research·Carla PetrellaCinzia Severini
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé

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