PMID: 8279093Jan 1, 1993

Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study

Urological Research
V SerrettaM Pavone-Macaluso


A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24h after epirubicin instillation.


Oct 1, 1989·Urology·A J Farha, D J Krauss
Oct 1, 1989·European Journal of Cancer & Clinical Oncology·F R BalkwillA E Lee
Jan 1, 1989·Urologia Internationalis·H TsujihashiT Kurita
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M TortiJ Hannigan
Feb 1, 1986·Urology·T MishinaS Nakagawa
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·L DenisM De Pauw


Nov 1, 1996·Seminars in Urologic Oncology·B J GitlitzR Figlin

Related Concepts

Intravesical Injection
Malignant Neoplasm of Urinary Bladder
Combined Modality Therapy
Drug Administration Schedule
RU 49637
Neoplasm Recurrence, Local
Proteins, Recombinant DNA

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