Correlation between compound muscle action potential amplitude and duration in axonal and demyelinating polyneuropathy

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Hatice TankisiAnders Fuglsang-Frederiksen

Abstract

To get a better understanding of pathophysiology in polyneuropathies (PNPs) by correlating compound muscle action potential (CMAP) amplitude with duration. A total of 145 motor nerve conduction studies (MNCS) in 53 axonal and 132 MNCS in 45 demyelinating PNPs were analyzed. Peroneal and tibial MNCS were done by surface stimulation while for median and ulnar nerves near nerve or surface stimulations were used. CMAP amplitude and duration were compared in axonal and demyelination PNPs. Relationships between amplitude and duration of distally and proximally evoked CMAP were examined using regression analysis. CMAP amplitude was lower and duration was increased in all examined nerves in demyelinating PNPs than in axonal PNPs. In demyelinating PNPs, an inverse linear correlation between amplitude and duration was seen in distally and proximally evoked CMAP in all examined nerves. In axonal PNPs, there was no correlation in any of the nerves neither in distally nor in proximally evoked CMAP. Distal CMAP duration and the relationship between CMAP amplitude and duration show supplementary electrodiagnostic potential in demyelinating PNPs. More knowledge about the relation between amplitude and duration in axonal lesions and demyelinati...Continue Reading

References

Feb 24, 2001·Neurophysiologie clinique = Clinical neurophysiology·B Johnsen, A Fuglsang-Frederiksen
May 24, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hatice TankisiUNKNOWN Esteem Project
May 26, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pietro CaliandroLuca Padua
Sep 29, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hatice TankisiAnders Fuglsang-Frederiksen
May 10, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pietro CaliandroLuca Padua
Dec 19, 2008·Journal of the Neurological Sciences·C L KoskiD R Cornblath
Nov 17, 2009·Journal of the Peripheral Nervous System : JPNS·Sagiri IsoseUNKNOWN Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group
Aug 3, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anders Fuglsang-Frederiksen, Kirsten Pugdahl

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Citations

Feb 3, 2016·The Veterinary Journal·Inge D Wijnberg, Hessel Franssen
Jun 8, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sansuthan ParamanathanAnders Fuglsang-Frederiksen
Oct 2, 2015·Intensive Care Medicine·Eddy Fan, Margaret S Herridge
Nov 6, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Hatice TankisiAnders Fuglsang-Frederiksen

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Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
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Journal of the Peripheral Nervous System : JPNS
Sagiri IsoseTokyo Metropolitan Neuromuscular Electrodiagnosis Study Group
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Anders Fuglsang-Frederiksen, Kirsten Pugdahl
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