May 9, 2012

Correlation between coronary perfusion pressure and quantitative ECG waveform measures during resuscitation of prolonged ventricular fibrillation

Joshua C ReynoldsJames J Menegazzi


The ventricular fibrillation (VF) waveform is dynamic and predicts defibrillation success. Quantitative waveform measures (QWMs) quantify these changes. Coronary perfusion pressure (CPP), a surrogate for myocardial perfusion, also predicts defibrillation success. The relationship between QWM and CPP has been preliminarily explored. We sought to further delineate this relationship in our porcine model and to determine if it is different between animals with/without ROSC (return of spontaneous circulation). A relationship exists between QWM and CPP that is different between animals with/without ROSC. Utilizing a prior experiment in our porcine model of prolonged out-of-hospital VF cardiac arrest, we calculated mean CPP, cumulative dose CPP, and percent recovery of three QWM during resuscitation before the first defibrillation: amplitude spectrum area (AMSA), median slope (MS), and logarithm of the absolute correlations (LAC). A random effects linear regression model with an interaction term CPP ROSC investigated the association between CPP and percent recovery QWM and how this relationship changes with/without ROSC. For 12 animals, CPP and QWM measures (except LAC) improved during resuscitation. A linear relationship existed betw...Continue Reading

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Mentioned in this Paper

Coronary Circulation
Ventricular Fibrillation
Physiologic Pulse
Vascular Resistance
Basic Cardiac Life Support
Coronary Arteriosclerosis
Myocardial Blood Flow

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