Correlation between corpus callosum shape and cognitive performance in healthy young adults

Brain Structure & Function
Manuel Martin-LoechesRoberto Colom

Abstract

Corpus callosum (CC) might be related to cognitive performance because of its role in interhemispheric communication. Previous research has focused mainly on volumetric analyses of the CC, yielding contradictory results to some extent. Shape is an approach that integrates and extends the data obtained with the volumetric methodology. Here, we analyze the relationships between midsagittal CC shape variation and several cognitive measures. 2D coordinates from 102 MRI-scanned young adult human CCs were superimposed through a Procrustes approach. The residual variation was regressed onto 21 cognitive measures completed by the participants. Most of these measures (including general intelligence, working memory, executive functioning, and mental speed) were unrelated to midsagittal CC morphology. However, attentional control did show consistent and significant correlations with CC shape variation. Slower responses in attentional control were systematically associated with more curved and thinner CC, with consequent rotation of the splenium and the genu. Although the magnitude of the correlations suggests a small relationship of midsagittal CC geometry and attention, the results provide interesting clues regarding the links between br...Continue Reading

References

May 1, 1992·Biological Psychiatry·R A BornsteinH A Nasrallah
Jan 1, 1989·Progress in Neurobiology·M A Hofman
Jul 1, 1969·Journal of Experimental Psychology·J R Simon
Dec 17, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M I Posner, M K Rothbart
Jan 6, 2001·Developmental Neuropsychology·M T Banich, W S Brown
Jul 21, 2001·Annals of the New York Academy of Sciences·J N GieddF X Castellanos
Jan 5, 2002·Journal of Experimental Psychology. General·Akira MiyakeMary Hegarty
Feb 22, 2002·Neuroscience and Biobehavioral Reviews·Fabienne Collette, Martial Van der Linden
Jul 16, 2002·Systematic Biology·F J Rohlf, M Corti
May 20, 2004·Journal of Experimental Psychology. General·Michael J KaneRandall W Engle
Aug 25, 2004·NeuroImage·Richard J HaierMichael T Alkire
Sep 15, 2004·European Archives of Psychiatry and Clinical Neuroscience·Christine M BornGerda L Leinsinger
Mar 10, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Joan T RichtsmeierTheodore M Cole
Mar 25, 2006·PLoS Computational Biology·Claus C Hilgetag, Helen Barbas
Feb 23, 2007·Neuroreport·Eileen LudersCarlo Caltagirone
Aug 8, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Emiliano Bruner
Aug 11, 2007·NeuroImage·Eileen LudersArthur W Toga
Dec 7, 2007·Archives of Pediatrics & Adolescent Medicine·Matthew AllinRobin Murray
Mar 29, 2008·Brain : a Journal of Neurology·Jennifer ParkerMatthew Allin
Apr 1, 2008·Biological Psychiatry·Steven J Luck, James M Gold
Jun 20, 2008·Schizophrenia Research·Mark WalterfangChristos Pantelis
Oct 10, 2008·Biological Psychiatry·Eileen LudersJennifer G Levitt
Oct 25, 2008·Experimental Brain Research·Amanda D HutchinsonMarie T Banich
Nov 21, 2008·Journal of Affective Disorders·Mark WalterfangNicholas B Allen
Jun 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mark WalterfangSophia Frangou
Feb 13, 2010·Neuroscience and Behavioral Physiology·V M VerkhlyutovYu A Pirogov
Mar 25, 2011·Molecular Ecology Resources·Christian Peter Klingenberg
Mar 25, 2011·European Archives of Psychiatry and Clinical Neuroscience·Guillermo HorgaMonte S Buchsbaum
Dec 20, 2011·Schizophrenia Research·Charlie A DavidsonJames J Levitt
Jun 1, 2010·Translational Neuroscience·Manuel F CasanovaAndrew E Switala

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Citations

Nov 26, 2015·Journal of the American Statistical Association·Chao HuangHongtu Zhu
Jan 9, 2014·Journal of Anatomy·Emiliano BrunerHeidi I L Jacobs
Dec 6, 2016·The Spanish Journal of Psychology·Anja Pahor, Norbert Jaušovec
May 12, 2018·Journal of Neuroscience Research·Florian KurthEileen Luders
Apr 3, 2015·Human Brain Mapping·Daniel M PrendergastPhilip R Szeszko

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