PMID: 3986169Apr 1, 1985

Correlation between cytoplasmic steroid receptors and tumour differentiation and invasion in endometrial carcinoma

British Journal of Obstetrics and Gynaecology
M A QuinnM Cauchi

Abstract

The incidence and levels of cytoplasmic steroid receptors were studied in 155 endometrial carcinomas: oestrogen receptors (ER) were measured in all samples, progesterone receptors (PR) in 148 and androgen receptors (AR) in 118. Well-differentiated adenocarcinomas were significantly more likely to contain ER, PR and AR than were poorly-differentiated tumours, and mean values of ER and PR content were significantly higher in well-differentiated adenocarcinomas than in less-differentiated tumours. Receptor profiles in adenosquamous carcinomas and clear-cell carcinomas were similar to those in adenocarcinomas. Deeply invasive tumours were significantly less likely to be ER, PR or AR positive and, even when positive, such tumours had significantly lower mean levels of ER and PR. Poorly-differentiated tumours were significantly more likely to be ER-negative PR-positive than well-differentiated adenocarcinomas and adenosquamous carcinomas.

References

Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·D T MacLaughlin, G S Richardson
Jun 1, 1976·American Journal of Obstetrics and Gynecology·P C YoungR E Cleary
Oct 1, 1979·Gynecologic Oncology·R HähnelE Twaddle
Mar 1, 1978·American Journal of Surgery·W S FletcherC E Davenport
Jan 1, 1978·Acta Obstetricia Et Gynecologica Scandinavica·L G FribergC B Korsten
Jul 1, 1974·The Journal of Endocrinology·S G CrockerR J King
Dec 1, 1967·The Journal of Endocrinology·M G BrushR J King
Sep 1, 1982·British Journal of Obstetrics and Gynaecology·M A QuinnR J Pepperell

Related Concepts

Carcinoma, Cribriform
Protoplasm
Myometrium
Neoplasm Invasiveness
Androgen Receptor
Estrogen Nuclear Receptor
Receptors, Progesterone
Receptors, Steroid
Uterine Cancer

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