PMID: 11327545May 1, 2001Paper

Correlation between decreased type-II interleukin-1 receptor and increased monocyte chemotactic protein-1 expression in the endometrium of women with endometriosis

American Journal of Reproductive Immunology : AJRI
Abdelaziz Kharfi, A Akoum

Abstract

Monocyte chemotactic protein-1 (MCP-1), a potent inducer of macrophage recruitment and activation, is overexpressed in the eutopic endometrium of women with endometriosis. Eutopic endometrial cells of women with endometriosis secrete higher levels of MCP-1 than those of normal women, following stimulation with interleukin-1 (IL-1). The aim of this study was to examine whether there is any correlation between the expression of IL-1 receptor type II (IL-IRII), a specific downregulator of IL-1 activity, and that of MCP-1 in the eutopic endometrium of women with endometriosis. Endometrial biopsies of 46 women with endometriosis and 22 healthy women were evaluated simultaneously for IL-1RII and MCP-1 expression by immunohistochemistry. Our study revealed a highly significant correlation between the decreased expression of IL-1RII and the increased expression of MCP-1 in the endometrial tissue of women with endometriosis (Spearman correlation coefficient r = -0.377, P = 0.002), particularly in the initial stages of the disease (stages I and II; r = - 0.368, P = 0.020 and r = -0.480, P = 0.002, respectively). Furthermore, this correlation was observed in the proliferative (r = -0.366, P = 0.047) and the secretory phases (r = -0.321, P...Continue Reading

Citations

Jun 16, 2011·Human Reproduction Update·K E MayC M Becker
Nov 30, 2013·Human Reproduction·G M BorrelliS Mechsner
Aug 17, 2006·American Journal of Reproductive Immunology : AJRI·Paulo D'AmoraEduardo Schor
Sep 10, 2010·American Journal of Reproductive Immunology : AJRI·Yu TaoWanying Luo
Dec 6, 2014·Oxidative Medicine and Cellular Longevity·Mohamed M HafezMohamed M Sayed-Ahmed
Mar 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A Gressner, Chunfang Gao
May 5, 2012·Reproductive Sciences·Xiu-Hong ZhangZeng-Ming Yang
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Oct 5, 2019·American Journal of Reproductive Immunology : AJRI·Ting QuJiang Gu
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samira AsghariMehdi Yousefi

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