Correlation between degree of subvoxel spinal cord compression measured with super-resolution tract density imaging and neurological impairment in cervical spondylotic myelopathy

Journal of Neurosurgery. Spine
Benjamin M EllingsonLangston T Holly

Abstract

OBJECT The purpose of this study was to explore the use of super-resolution tract density images derived from probabilistic diffusion tensor imaging (DTI) tractography of the spinal cord as an imaging surrogate for microstructural integrity and functional impairment in patients with cervical spondylosis. METHODS Structural MRI and DTI images were collected for 27 patients with cervical spondylosis with (n= 21) and without (n= 6) functional impairment as defined by the modified Japanese Orthopaedic Association Scale (mJOA). DTI was performed axially through the site of compression in a total of 20 directions with 10 averages. Probabilistic tractography was performed at 0.5-mm isotropic spatial resolution using the streamline technique combined with constrained spherical deconvolution. The following measurements were calculated for each patient: maximum tract density at the site of compression, average tract density in rostral normal-appearing spinal cord, and the ratio of maximum density to normal density. RESULTS Compared with normal tissue, the site of compression exhibited elevated fiber tract density in all patients, and a higher fiber tract density was also noted in focal areas at the site of compression in patients with fu...Continue Reading

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Citations

Apr 21, 2016·Scientific Reports·Patrick GrabherPatrick Freund
Mar 18, 2017·Journal of Neurosurgery. Spine·Sorin C CraciunasCarmen M Cirstea
Aug 31, 2020·The Bone & Joint Journal·Hanwen ZhangXiaolong Chen
Mar 5, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hong WangXiaowen Jia
Mar 28, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Rebecca J CrawfordJames M Elliott
Sep 24, 2019·Journal of Neurotrauma·Maryam SeifPatrick Freund
Mar 30, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chencai WangBenjamin M Ellingson

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