PMID: 11337179May 5, 2001Paper

Correlation between detection methods of Chlamydia pneumoniae in atherosclerotic and non-atherosclerotic tissues

Diagnostic Microbiology and Infectious Disease
Boulos MarahaM Peeters

Abstract

Polymerase chain reaction (PCR) and immunohistochemistry (IHC) have been used to detect Chlamydia (C.) pneumoniae in vascular tissues. Discrepancies between the results of these two methods have frequently been reported. However, the correlation between PCR and IHC has not been analyzed yet. This study assesses the correlation between the detection of C. pneumoniae by PCR and IHC in 45 atherosclerotic and 50 non-atherosclerotic tissue specimens. Also, the presence of Mycoplasma (M.) pneumoniae in these 95 specimens was investigated. Correlation was found between the detection of C. pneumoniae by PCR and IHC in the atherosclerotic tissues. Both tests were positive in 10 specimens and negative in 17 specimens (p = 0.003). There was no significant correlation between PCR and IHC in non-atherosclerotic specimens (p = ns). M. pneumoniae was detected, by PCR, in one atherosclerotic specimen.The results show correlation between PCR and IHC in the detection of C. pneumoniae in atherosclerotic tissues, emphasize the association between C. pneumoniae and atherosclerosis, and support the specificity of the association between C. pneumoniae and atherosclerosis.

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Citations

May 7, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Harald C WormHerwig Holzer
Sep 15, 2004·Journal of Clinical Microbiology·Boulos MarahaAnneke van der Zee
Jan 7, 2005·Journal of Clinical Microbiology·Margareta M Ieven, Vicky Y Hoymans
Feb 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Bogdan JegierMalgorzata Lelonek
Apr 12, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Edyta ReszkaRyszard Jaszewski
Nov 19, 2003·Cardiology Clinics·Joseph B Muhlestein, Jeffrey L Anderson
Feb 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H F BergM F Peeters

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