Correlation between detrusor collagen content and urinary symptoms in patients with prostatic obstruction

The Journal of Urology
Vincenzo MironeF Fusco

Abstract

We used computerized imaging analysis to compare the collagen content of detrusor specimens between patients affected with symptomatic obstructive benign prostatic hyperplasia (BPH) and asymptomatic controls. In our study we enrolled 36 patients with symptomatic urodynamically obstructed BPH undergoing transurethral resection of the prostate. We also enrolled 28 men (mean age 61.3, range 55 to 70) undergoing transurethral resection of the bladder for primitive, singular Ta bladder cancer, with no significant urinary symptoms, as the control group. During the transurethral surgical procedure in controls and in patients with BPH, a biopsy was performed deep through the muscular layer from either of the lateral bladder walls. Computerized morphometric analysis of the stained sections was performed with an image analysis system, and a percentage of collagen fibers was extracted through morphological filtering and expressed as a mean percentage of the total bioptic area. Collagen content in bladder detrusor specimens was significantly higher in patients with BPH compared to controls (48% and 17% of bioptic area, respectively, p <0.001). Mean detrusor collagen content was clearly higher in patients with severe symptoms than in patien...Continue Reading

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Citations

May 20, 2006·World Journal of Urology·Abdel-Rahmène AzzouziAlexandre de la Taille
Sep 14, 2007·Scandinavian Journal of Urology and Nephrology·Jasper van der WijkJean de la Rosette
Sep 18, 2012·Medicina clínica·Carlos Hernández FernándezIgnacio Moncada Iribarren
Nov 11, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Xiangdong Li, Nafis Rahman
Jun 14, 2008·Neurourology and Urodynamics·K P WolffenbuttelD J Kok
May 20, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Guevar MaselliCarlo Vicentini
May 9, 2012·International Journal of Experimental Pathology·Patrícia S de Almeida PradoVicente P C Teixeira
Sep 19, 2006·European Urology·Vincenzo MironeFerdinando Fusco
Sep 26, 2017·Neurourology and Urodynamics·Marcio A AverbeckErnani L Rhoden
Jul 13, 2006·American Journal of Physiology. Renal Physiology·John A TaylorGeorge A Kuchel
Jul 7, 2019·Neurourology and Urodynamics·Ruud BoschEskinder Solomon
Nov 21, 2013·Current Opinion in Urology·Altaf Mangera, Christopher Chapple
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Long-Hu JinTack Lee
May 26, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sher Singh YadavTrilok Chandra Sadasukhi
Sep 29, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Takeya KittaNobuo Shinohara
Oct 23, 2020·Lower Urinary Tract Symptoms·Kareman EljamalToshiyuki Sasaguri
Dec 4, 2020·International Neurourology Journal·Su Jin Kim

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