Correlation Between E6 and E7 Oncogenes and Malignant Transformation of Laryngeal Papillomatosis (LP) with Human Papillomavirus (HPV) in Pediatric Population.

Fetal and Pediatric Pathology
Zaid KhreefaBahig M Shehata

Abstract

Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods: Among 187 patients identified in our institution with LP, four cases showed malignant transformation to invasive squamous carcinoma. Results: These patients had tumors with HPV viruses that showed high expression of oncogene E6 and E7 and low expression of E2. Conclusion: Malignant transformation of LP is associated with oncogenic expression of E6 and E7.

References

Feb 24, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·R RabahL Gregoire
Nov 10, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Bahig M ShehataCharles E Hill
Aug 10, 2017·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Katarzyna NowińskaPiotr Dzięgiel
Oct 17, 2017·Papillomavirus Research·Brenda Y HernandezMona Saraiya
Jun 13, 2018·International Journal of Molecular Sciences·Nicole S L Yeo-TehSudhakar Jha
Jan 22, 2019·Case Reports in Otolaryngology·Vivian Narana Ribeiro El-AchkarEstela Kaminagakura
Feb 26, 2019·American Journal of Otolaryngology·Maïmouna IlboudoJacques Simpore

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