Abstract
The existence of endogenous cardiac glycoside-like compounds and their property of being recognized by anti-digoxin antibodies is still a matter of controversy. In order to investigate this problem, endogenous digoxin-like immunoreactivity (measured by RIA) and digitalis-like radioreceptor activity (measured by displacement of 3H-ouabain from erythrocyte membranes) were assessed in plasma extracts of normal adults, pregnant women and newborns. These three groups were chosen because of their known widely different levels of digoxin-like immunoreactivity. Compared to adults, newborns and pregnant women had significantly higher levels not only of immunoreactivity but also of displacement of 3H-ouabain binding, the latter being due, according to Scatchard analysis, to a decrease of the affinity of ouabain to its cellular receptor rather than to its maximal binding capacity. Furthermore, immunoreactivity and binding displacement correlated significantly. Our data indicate that one (or more) compounds with cardiac glycoside-like properties (both immunological and at the receptor level) are present in the plasma of newborns and pregnant women, and confirm the idea that radioimmunological methods may be useful in studying endogenous in...Continue Reading
References
May 24, 1979·Nature·J S FlierD McIsaac
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A R GintzlerS Spector
Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·S W Graves, G H Williams
Nov 27, 1984·European Journal of Pharmacology·M Hnatowich, F Labella
Oct 15, 1984·FEBS Letters·M CrabosJ F Cloix
Oct 23, 1980·Nature·K A GruberV M Buckalew
May 1, 1982·Hypertension·K A GruberB C Bullock
Dec 16, 1982·Nature·J M HamlynM P Blaustein
Sep 3, 1983·British Medical Journal·M A DevynckP Meyer
Jul 18, 1984·Biochemical and Biophysical Research Communications·I Kojima
Jan 1, 1981·Journal of Molecular and Cellular Cardiology·V SchreiberT Pribyl
Oct 1, 1984·Clinical Biochemistry·S J SoldinP Olley
Apr 14, 1983·The New England Journal of Medicine·M R PudekE Ling
Jun 1, 1983·The Journal of Pediatrics·R ValdesM Landt
Oct 1, 1982·Klinische Wochenschrift·D KlingmüllerH J Kramer
Citations
Dec 1, 1994·Journal of Clinical Pharmacology·W A Colburn
Mar 1, 1990·Cardiovascular Drugs and Therapy·L Poston
Jan 1, 1997·Life Sciences·M Paskvalin, J C Khatter
Jul 1, 1994·European Journal of Clinical Investigation·R H StraubJ Schölmerich
Oct 1, 1990·British Journal of Pharmacology·S NavaratnamJ C Khatter
May 1, 1996·British Journal of Pharmacology·C Han, J C Khatter
May 1, 1992·Journal of Endocrinological Investigation·A Clerico, G Mariani
Jan 1, 1994·The American Journal of the Medical Sciences·E W WeilerM A Weber
Aug 1, 1994·Kidney International·R G WoolfsonH E de Wardener
May 1, 1994·Endocrine Research·C FerriF Balsano
Jun 23, 2018·Clinical Science·Vardaman M Buckalew