PMID: 16646402May 2, 2006Paper

Correlation between expression of the MTA1 gene and carcinomas of larynx

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Huihe WangGuoqian Kuang

Abstract

To study the relation between Mta1 gene (metastasis associated gene, meta gene) and lymph node metastasis of laryngeal carcinomas. Reverse transcription polymerase chain reaction(RT-PCR) technique was used to detect the expression of Mta1 mRNA in 30 carcinoma of larynx tissue cases, 12 lymph nodes and 10 normal larynx tissue cases. The frequency of MTA1 overexpression was 100% (8/8) in primary carcinomas of larynx with metastasis but only 22.7% (5/22) in toes without metastasis (P<0.01). Expression of MTA1 was 87.5%(7/8) in lymph nodes with metastasis but only 0(0/4) in toes without metastasis(P<0.05). The frequency of Mta1 overexpression was 43.3% (13/30) in primary carcinomas of larynx. Our data suggest that the overexpression of the MTA1 gene correlates with lymph node metastasis of carcinomas of larynx. Mta1 gene will probably become a valuable gene for judging metastasis of laryngeal carcinoma.

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