Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma?

Annals of Nuclear Medicine
Rintaro ItoShinji Naganawa

Abstract

The maximum standardized uptake value (SUVmax) of FDG-PET/CT is commonly used as an indicator to evaluate the invasiveness and prognosis of non-small-cell lung cancers (NSCLC). We investigated the correlation between SUVmax and tumor invasiveness or postoperative recurrence of solid type NSCLC and compared squamous cell carcinoma (SCC)/adenosquamous carcinoma (ASC) to adenocarcinoma (AC). A retrospective review of preoperative PET/CT, thin-section CT, and postoperative pathological records obtained over a 5-year period was conducted. Solid type NSCLC tumors on thin-section CT with confirmed diagnosis from surgical resection (diameter ≤3 cm) were included. Multivariate logistic regression was used to evaluate the correlation between tumor characteristics and pathological prognostic factors or postoperative recurrence. 150 patients (111 males, 39 females; mean age 67 years; 106 cases of AC, 36 cases of SCC, and 8 cases of ASC) were included. SUVmax was significantly correlated with pleural involvement (p = 0.047), lymphatic permeation (p = 0.003), lymph node metastasis (p = 0.027), and tumor invasiveness (p < 0.001). Receiver operating characteristic analysis indicated an optimal SUVmax threshold of 5.0 for tumor invasiveness. Hi...Continue Reading

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Citations

Jun 22, 2018·Nihon Hoshasen Gijutsu Gakkai zasshi·Noriaki MiyajiMitsuru Koizumi
Jun 9, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Shingo IwanoShinji Naganawa
Jul 10, 2020·Insights Into Imaging·Patricia E MelendezKatherine Kaproth-Joslin
Jul 28, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hironori ShimamotoShinji Naganawa
Feb 26, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fengxian ZhangLei Jiang
Mar 11, 2017·Journal of Nuclear Medicine Technology·Noriaki MiyajiMitsuru Koizumi

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