PMID: 9426021Jan 13, 1998Paper

Correlation between hemodynamic changes and tomographic sestamibi imaging during dipyridamole-induced coronary hyperemia

Journal of the American College of Cardiology
J D OgilbyA S Iskandrian

Abstract

The purposes of this study were to examine the effects of dipyridamole infusion on hemodynamic variables and to compare these changes with myocardial perfusion. Dipyridamole stress testing with myocardial perfusion imaging is widely used in the assessment of patients with known or suspected coronary artery disease (CAD). Few studies, however, have correlated the hemodynamic effects of dipyridamole using invasive monitoring with perfusion patterns in patients with chest pain syndromes. Hemodynamic measurements were made in the cardiac catheterization laboratory with a Swan-Ganz thermodilution catheter before, during and after infusion of dipyridamole (142 microg/kg body weight per min for 4 min). Technetium-99m sestamibi was injected 3 min after the completion of the infusion. There were 20 patients with and 6 without CAD, as demonstrated by angiography. Compared with baseline values, dipyridamole resulted in an increase in pulmonary capillary wedge pressure (54 +/- 78% vs. 32 +/- 26%, p = NS), cardiac index (36 +/- 21% vs. 40 +/- 18%, p = NS) and stroke volume index (16 +/- 18% vs. 40 +/- 18%, p = NS) and a decrease in systemic vascular resistance (22 +/- 13% vs. 24 +/- 11%, p = NS), aortic pressure (2 +/- 9% vs. 0 +/- 6%, p = ...Continue Reading

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Citations

May 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·S R UnderwoodUNKNOWN Royal College of Radiologists
Nov 22, 2001·American Heart Journal·C KimR Redberg
May 25, 2004·Nuclear Medicine Communications·Gulay Durmus AltunSakir Berkarda
Feb 11, 2010·Nuclear Medicine Communications·Seyed Rasoul ZakaviVahid Reza Dabbagh Kakhki
Oct 28, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francois HarelMatthieu Pelletier-Galarneau

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