Correlation between histological subtypes and MRI findings in clinically nonfunctioning pituitary adenomas.

Endocrine Pathology
Hiroshi NishiokaShozo Yamada

Abstract

Clinically nonfunctioning pituitary adenomas (CNFPAs) consist of several histological subtypes, including null cell adenoma (NCA), silent gonadotroph cell adenoma (SGA), silent corticotroph adenoma (SCA), and other silent adenomas (OSA) (i.e., GH, TSH, and prolactin adenomas). To detect possible correlations between MRI findings and the subtypes, we retrospectively studied 390 consecutive patients with CNFPA who underwent surgery between 2008 and 2010. They were classified into three groups: NCA/SGA (313 cases), SCA (39 cases), and OSA (36 cases); in addition there were two unusual cases of plurihormonal adenoma. Three MRI findings were less common in NCA/SGA than in the other groups (P < 0.0001): giant adenoma (>40 mm), marked cavernous sinus invasion (Knosp grade 4), and lobulated configuration of the suprasellar tumor. When these MRI findings were negative in patients older than 40 years old, 91.0% (212/233) were NCA/SGA. These MRI findings were frequently noted despite a low MIB-1 index in SCA. OSA showed a high MIB-1 index and a preponderance in younger patients. In conclusion, although SCA and OSA consisted of only 20% of CNFPAs, their frequency significantly increased when the tumor was large, invasive, and lobulated, an...Continue Reading

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Citations

Jul 12, 2014·Journal of Neurosurgery·Edward H Oldfield
Sep 17, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Rosa Cámara Gómez
Mar 8, 2014·Clinical Endocrinology·Laure CazabatStéphan Gaillard
Jan 9, 2020·Reviews in Endocrine & Metabolic Disorders·Christina Tatsi, Constantine A Stratakis
Oct 26, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Bette K Kleinschmidt-DeMasters
Apr 9, 2020·Archives of Endocrinology and Metabolism·Josefina RosminoMirtha Guitelman
Apr 25, 2020·International Journal of Molecular Sciences·Shinsuke UrakiTakashi Akamizu
May 26, 2021·Archives of Endocrinology and Metabolism·Josefina RosminoMirtha Guitelman
Jun 4, 2019·Annals of Diagnostic Pathology·Geraldine TrottJulia Fernanda Semmelmann Pereira-Lima
Aug 16, 2017·Endocrinología, Diabetes Y Nutrición·Moises MercadoDalia Cuenca

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