Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction

Transplantation
Junchao CaiS J Knechtle

Abstract

In this study, we determined whether Campath-1H induction followed by sirolimus monotherapy inhibited alloantibody production in renal transplantation. Second, we evaluated the correlation between human leukocyte antigen (HLA) antibody production and serum creatinine levels. Sera were taken 1 to 24 months after transplantation from 24 patients treated with Campath-1H and sirolimus and tested for serum creatinine and HLA-specific antibody by using flow cytometry and enzyme-linked immunosorbent assay. Ten (42%) of the 24 patients treated with Campath-1H and sirolimus produced HLA antibodies. Six of these 10 developed both donor-specific antibodies (DSAs) and non-donor-specific antibodies (NDSAs), whereas only NDSAs were detected in the other four patients. In patients with biopsy-diagnosed humoral rejection (C4d+), serum levels of both DSA and NDSA significantly correlated with patient serum creatinine levels. Rejection treatment successfully reduced both DSAs and NDSAs and reversed humoral rejection. The numeric relationship between serum creatinine and DSA levels suggests a causal relationship between alloantibody and transplant rejection.

References

Apr 3, 1969·The New England Journal of Medicine·R Patel, P I Terasaki
Oct 1, 1993·Current Opinion in Immunology·H Waldmann, S Cobbold
Aug 1, 1996·Chest·A E FrostP T Cagle
Aug 13, 2002·Cytotherapy·P RebelloG Hale
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Helmut E Feucht
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paul I Terasaki
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart J KnechtleHans W Sollinger
Jun 24, 2003·Transplantation·François KleinclaussPhilippe Saas
Sep 2, 2003·Transplantation Proceedings·G CatalanoF Filipponi
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paul I Terasaki, Miyuki Ozawa

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Citations

Jul 22, 2005·Surgery Today·Junchao Cai, Paul I Terasaki
Jul 25, 2007·Nature Clinical Practice. Nephrology·M Javeed Ansari, Mohamed H Sayegh
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Helmut E Feucht, Michael J Mihatsch
Jan 16, 2007·Transplantation·Quanzong MaoLorita Rebellato
Aug 14, 2008·Transplantation·Paul I Terasaki, Junchao Cai
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stuart J Knechtle
Feb 18, 2010·Expert Review of Clinical Immunology·Ronald F ParsonsHooman Noorchashm
Oct 5, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Rolf N BarthStuart J Knechtle
Nov 18, 2008·Transplantation Proceedings·J PéfaurL Contreras
Apr 1, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Montserrat RigolMagda Heras
Mar 29, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Harold Yang
Jun 16, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D BloomS Knechtle
Oct 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J CaiL Rebellato
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S J KnechtleH W Sollinger
Aug 5, 2008·Clinical Transplantation·Ajda T RowshaniIneke J M Ten Berge
Jul 7, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W E UberN L Pereira
Mar 17, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Eugenia K PageStuart J Knechtle
Jul 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E K PageS J Knechtle
Mar 8, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·John C LaMattinaJohn D Pirsch
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N K Tchao, L A Turka
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HeidtK J Wood
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KwunN N Iwakoshi
Dec 3, 2016·Transplantation·Jean KwunStuart J Knechtle
Feb 3, 2007·Circulation Research·Jennifer WehnerWilliam M Baldwin
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stanley C Jordan, Mark D Pescovitz
Jul 23, 2019·Transplantation Reviews·R Laguna-GoyaE Paz-Artal

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