PMID: 30820201Mar 2, 2019Paper

Correlation between human neutrophil peptide 1-3 secretion and azurophilic granule (CD63) expression in early childhood caries

Dental Research Journal
Muhammad LuthfiYoes Prijatna Dachlan

Abstract

In saliva, neutrophil constitutes the most prominent first-line defense of immune cells against pathogenic microbes. The importance of neutrophils to the host immune systems of neutropenic or patients disabled with regard to their neutrophil function results in a tendency toward serious infections, such as early childhood caries (ECC). The cytoplasmic granules present in neutrophils play a major role in neutrophil-mediated inflammation. Azurophilic granules contain antimicrobial proteins, such as defensin, a human antimicrobial peptide (HNP 1-3). The aim of this study is to analyze the correlation of HNP 1-3 secretion with CD63 expression on the surface of salivary neutrophils. This study constituted a cross-sectional, analytical observational study. Saliva taken from preschoolchildren between the ages of 4-6 years who had been divided into two groups, i.e., early childhood caries group with decayed, extracted, filled teeth (def-t) index >6 and caries free with def-t = 0, was subjected to a HNP 1-3 secretion test using ELISA assay and an expression test for CD63 by means of a flow cytometry test. The results obtained were analyzed using independent t-test and Pearson correlation (P < 0.05). The secretion of HNP 1-3 in the saliv...Continue Reading

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

European Journal of Paediatric Dentistry : Official Journal of European Academy of Paediatric Dentistry
A VaniaA Polimeni
Journal of Dental Research, Dental Clinics, Dental Prospects
Masoumeh MoslemiMohammad Saeid Shadkar
© 2022 Meta ULC. All rights reserved