Correlation between Immunohistochemical and Histomorphological Features of Ampullary Carcinomas: A Study on 72 Cases from a Tertiary Health Care Center

Gastroenterology Research and Practice
Usha Mary Abraham, Subramaniam Ramkumar

Abstract

Tumors involving the ampulla could be arising primarily in the ampulla or extending from the adjacent. When a neoplasm is centered primarily in the ampulla with or without periampullary mucosal involvement, it is considered a primary ampullary carcinoma. These tumors generally have a better prognosis than duodenal and pancreaticobiliary neoplasms secondarily involving the ampulla. Distinguishing between the two primary types has prognostic implications, as the pancreaticobiliary-type ampullary carcinomas are said to have a poorer prognosis than the intestinal-type. Morphological analysis alone may not suffice in this context. The role of immunohistochemistry has therefore been explored by various groups of workers. The purpose of the present study was to determine the role of morphology and cytokeratin profile in accurate typing of ampullary carcinomas as intestinal and pancreaticobiliary.

References

Feb 1, 1994·Japanese Journal of Cancer Research : Gann·W KimuraY Esaki
Jul 22, 1998·Annals of Surgery·J R HoweM F Brennan
Aug 3, 2000·Archives of Pathology & Laboratory Medicine·J V DuvalB F Banner
Jun 30, 2004·The American Journal of Surgical Pathology·Hui ZhouHans-Peter Fischer
Nov 19, 2004·Journal of Hepato-biliary-pancreatic Surgery·Hans-Peter Fischer, Hui Zhou
Nov 30, 2004·Annales de pathologie·Florence Le PessotJosette Métayer
Sep 3, 2008·BMC Cancer·Peter Schirmacher, Markus W Büchler
Dec 24, 2009·Toxicologic Pathology·J T PainterR A Herbert
Feb 2, 2011·Pathology, Research and Practice·Reyhan BayrakHacer Haltas

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