Correlation between infectivity and physical virus particles in human cytomegalovirus.

Journal of Bacteriology
M Benyesh-MelnickV Vonka

Abstract

Benyesh-Melnick, Matilda (Baylor University College of Medicine, Houston, Tex.), Fern Probstmeyer, Robert McCombs, Jean P. Brunschwig, and Vladimir Vonka. Correlation between infectivity and physical virus particles in human cyto-megalovirus. J. Bacteriol. 92:1555-1561. 1966.-Infectivity titers [measured as plaque-forming units (PFU)] and particle counts by the sedimentation pseudo-replication technique were determined for crude, unpurified, intracellular preparations of two different strains of human cytomegalovirus. Unlike the high particle-infectivity ratio of 10(6) to 10(8) previously reported for these viruses, the number of total particles per PFU ranged from 160 to 490 with strain AD-169 and from 176 to 1,050 for strain C-87. Interpretation of particle-PFU ratios of intracellular cytomegalovirus in terms of particle morphology is not conclusive at this time. The number of enveloped forms found varied between 0 and 34% of the total particles counted. However, the true proportion is probably greater, because envelopes were found to be destroyed by the enzyme treatment used in preparing the specimens for examination in the electron microscope. The number of full particles found ranged between 4 and 31% of the total particle...Continue Reading

References

Jan 1, 1966·Journal of Bacteriology·V Vonka, M Benyesh-Melnick
Jan 1, 1966·Journal of Bacteriology·V Vonka, M Benyeshmelnick
Jun 25, 1965·Journal of Bacteriology·R M McCombsJ P Brunschwig
Apr 1, 1963·Virology·C R GOODHEART, L B JAROSS
Jun 1, 1963·Journal of Bacteriology·K O SMITH, L RASMUSSEN
Nov 1, 1963·Journal of Bacteriology·K O SMITH
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·K O SMITH
Jul 1, 1964·Virology·H T WRIGHTA LIELAUSIS
Oct 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·G PLUMMER, M BENYESH-MELNICK
Nov 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·M BENYESH-MELNICKB WATSON

❮ Previous
Next ❯

Citations

Jul 22, 1971·The New England Journal of Medicine·T H Weller
Apr 21, 1983·The New England Journal of Medicine·S Chou, T C Merigan
Oct 21, 2014·Expert Review of Proteomics·Pierre M Jean Beltran, Ileana M Cristea
Sep 1, 1968·Journal of Virology·C Wallis, J L Melnick
Oct 1, 1971·Infection and Immunity·Y MinamishimaM Benyesh-Melnick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bacteriology
R M McCombsJ P Brunschwig
Journal of Bacteriology
V Vonka, M Benyeshmelnick
© 2021 Meta ULC. All rights reserved