Correlation between inflammation and oxidative stress in normocholesterolemic coronary artery disease patients 'on' and 'off' atorvastatin for short time intervals

Cardiovascular Drugs and Therapy
M K ThomasS K Maulik

Abstract

To assess whether variations in antioxidant and anti-inflammatory parameters occur with short term administration and discontinuation of atorvastatin in normocholesterolemic coronary artery disease (CAD) patients. Forty CAD patients with near normal serum cholesterol levels (total cholesterol <240 mg/dl, LDL cholesterol <130 mg/dl) were continuously enrolled and randomized to groups A and B (20 patients taking atorvastatin) and groups C and D (20 patients not taking atorvastatin). Atorvastatin (10 mg/day) was continued in group A, withdrawn in group B and started in groups C and D for 6 weeks. Thereafter atorvastatin was withdrawn in group A and C, restarted in group B, and continued in group D for further 6 weeks. CRP, FRAP and TBARS were assessed at baseline, 6 weeks and 12 weeks in all the groups. Baseline CRP, TBARS and FRAP levels were significantly different (p < 0.05) between groups A and B and C and D at the time of enrollment, indicating lower levels of oxidative stress (FRAP-172.40 +/- 23.41 nmol Fe(2+)/l vs 142.62 +/- 15.73 nmol Fe(2+)/l and TBARS-3.66 +/- 1.14 nmol/ml vs 6.11 +/- 1.85 nmol/ml) and low grade inflammation (CRP-1.38 +/- 0.69 mg/l vs 3.19 +/- 1.77 mg/l) in statin treated groups. In group B, discontinuat...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Jan 14, 1999·The New England Journal of Medicine·R Ross
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Apr 13, 2001·JAMA : the Journal of the American Medical Association·G G SchwartzUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
Jul 4, 2001·JAMA : the Journal of the American Medical Association·M A AlbertUNKNOWN PRINCE Investigators
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Antti JulaTapani Rönnemaa
Mar 27, 2002·Circulation·Christopher HeeschenUNKNOWN Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Investigators
May 8, 2002·Diabetes/metabolism Research and Reviews·P GargiuloV Sanguigni
May 16, 2002·European Heart Journal·W F RiesenG Noseda
Sep 23, 2003·Clinical Chemistry·Natalie KhuseyinovaWolfgang Koenig
Jan 27, 2004·The Annals of Pharmacotherapy·James M BackesPatrick M Moriarty
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina VassalleGian Carlo Zucchelli
Apr 9, 2004·The New England Journal of Medicine·Alan R Tall
May 19, 2004·Hypertension·Ishwarlal JialalSenthil K Venugopal
Jan 7, 2005·The New England Journal of Medicine·Paul M RidkerUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Inv
Apr 30, 2005·International Journal of Cardiology·Emmanouil KaratzisMyron Mavrikakis

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Citations

Dec 4, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Boris SchnorbusAscan Warnholtz
Jan 7, 2009·Cardiovascular Drugs and Therapy·Carlos V SerranoHugo P Monteiro
Oct 7, 2014·Cardiovascular Drugs and Therapy·Ling LiXiaowei Yan
Oct 18, 2011·Pharmacological Reports : PR·Magdalena Jasińska-StroscheinDaria Orszulak-Michalak
Jan 24, 2012·Journal of Clinical Lipidology·Jonathan R MurrowArshed A Quyyumi
Oct 26, 2010·Homeopathy : the Journal of the Faculty of Homeopathy·Marcus Zulian Teixeira
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rosalia LoPrestiGregorio Caimi
Oct 6, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Levent KebapcilarSena Yesil
Oct 8, 2014·Experimental and Therapeutic Medicine·Burak Cem Soner, Ayşe Saide Sahin

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