Correlation between insulin-like peptide 3 and appendix testis length in congenital cryptorchidism

Journal of Paediatrics and Child Health
Antonios PanagidisBessie E Spiliotis

Abstract

The appendix testis (AT) is a vestigial remnant of Müller's paramesonephric duct. Insulin-like 3 hormone (INSL3) is produced in the Leydig cells of the testis. We investigated the possible correlation between AT length and plasma INSL3 concentrations in patients with congenital cryptorchidism (CCO) and patients with hydrocele, who served as controls. A total of 40 patients with CCO and 34 patients with hydrocele and orthotopic testes were investigated. Sixteen patients presented high cryptorchidism and 24 low cryptorchidism. During surgery, AT was identified in 34 patients with CCO (high cryptorchidism:15, low cryptorchidism:19) and 28 controls. Plasma INSL3 levels were measured with a spectrophotometry enzyme immunoassay Elisa sandwich technique. AT was present in 85.0% of the boys with CCO and 82.4% of the controls. A significant positive correlation was found between the AT length and INSL3 concentrations in CCO patients. A longer AT may reflect better testicular function in boys with CCO, since it is correlated with higher INSL3 concentrations.

References

May 1, 1996·Clinical Radiology·K A Johnson, K C Dewbury
May 13, 1999·Molecular Endocrinology·S ZimmermannI M Adham
Jul 3, 1999·Nature Genetics·S Nef, L F Parada
May 16, 2001·Genesis : the Journal of Genetics and Development·P A OverbeekA I Agoulnik
Jan 26, 2002·Science·Sheau Yu HsuAaron J W Hsueh
Jul 13, 2002·The Journal of Biological Chemistry·Jin KumagaiAaron J W Hsueh
Aug 23, 2003·Molecular Endocrinology·Natalia V BogatchevaAlexander I Agoulnik
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro KawamuraAaron J W Hsueh
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Carlo ForestaAlberto Ferlin
Feb 15, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Luciano A FavoritoMarcio A Babinski
Jun 16, 2005·Annals of the New York Academy of Sciences·Alberto Ferlin, Carlo Foresta
Jun 21, 2005·Cell and Tissue Research·John M Hutson, Suzanne Hasthorpe
Feb 10, 2006·Biology of Reproduction·Ravinder J K Anand-IvellRichard Ivell
Oct 4, 2006·International Journal of Andrology·Ravinder Anand-IvellRichard Ivell
Feb 14, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Tamás JózsaCsongor Kiss
Apr 25, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alberto FerlinCarlo Foresta
May 16, 2008·Urologia Internationalis·Tamás JózsaTibor Flaskó
May 21, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Guilherme D TostesLuciano A Favorito
Jul 17, 2013·Nature Reviews. Endocrinology·Alberto FerlinCarlo Foresta
Oct 11, 2015·Bone·Marco Brotto, Lynda Bonewald
Apr 10, 2016·British Journal of Pharmacology·Alberto FerlinCarlo Foresta
Jun 1, 2018·BioMed Research International·Zlatan ZvizdicEmir Milisic
Oct 17, 2018·Frontiers in Endocrinology·Alberto FerlinCarlo Foresta
Aug 25, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Xenophon SinopidisBessie E Spiliotis

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.