Correlation between levofloxacin consumption and the incidence of nosocomial infections due to fluoroquinolone-resistant Escherichia coli

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Hui-Hsiu WuYuarn-Jang Lee

Abstract

The relationship between fluoroquinolone resistance in Escherichia coli isolates causing nosocomial infection and hospital antibiotic consumption were investigated. Restriction of levofloxacin use was implemented to control the incidence of fluoroquinolone-resistant E coli in the hospital. The study was conducted from January 2004 to December 2010. Antimicrobial agent consumption was obtained from the pharmacy computer system and presented as the defined daily doses per 1000 patient-days every 6 months. The incidence of fluoroquinolone-resistant E coli isolates causing nosocomial infections was obtained from the Department of Infection Control every 6 months. An antimicrobial stewardship program, restricting levofloxacain use, was implemented in July 2007. The incidence of fluoroquinolone-resistant E coli causing nosocomial infections was significantly correlated with fluoroquinolone usage (p = 0.005), but not with the use of third- or fourth-generation cephalosporins, piperacillin-tazobactam, or carbapenems. Parenteral (p = 0.002), oral (p = 0.018), and total levofloxacin (p = 0.001) use were significantly correlated with the extent of fluoroquinolone resistance. With a reduction of levofloxacin use, a decrease of the incidenc...Continue Reading

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Citations

Apr 23, 2016·Gastroenterology·Carlo A FalloneJohn K Marshall
Oct 10, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Rachael A LeePeter G Pappas
Nov 21, 2013·The Journal of Antibiotics·Radisa R Pavlovic, Slobodan M Jankovic
Mar 25, 2018·Current Infectious Disease Reports·Kimberly C ClaeysEmily L Heil

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