PMID: 25842870Apr 7, 2015

correlation between macro- and micro-stability C(H)2 domains of human IgG2 and their biological activity. II. Calculation of thermodynamic functions characterizing domains stability

Molekuliarnaia biologiia
V M Tishchenko

Abstract

The thermodynamic parameters of the stabilization of the native structure C(H)2 domains of human myeloma immunoglobulin LOM and SIN second subclass and their firstly obtained hFc fragments were determined using the methods of scanning microcalorimenry. A decrease in the termal stability and energy stability of the native of these domains in the intact proteins correlated in the "phisiological" range of temperatures (20-37 degrees C), mainly, with entropy factor.

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Related Concepts

Calorimetry
Polyglobin
Protein Denaturation
Thermodynamics
Tertiary Protein Structure
Entropy
Enzyme Stability
Immunoglobulin G
IgG2
Multiple Myeloma

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