Correlation between measles vaccine doses: implications for the maintenance of elimination

Epidemiology and Infection
A McKeeK Shea

Abstract

Measles eradication efforts have been successful at achieving elimination in many countries worldwide. Such countries actively work to maintain this elimination by continuing to improve coverage of two routine doses of measles vaccine following measles elimination. While improving measles vaccine coverage is always beneficial, we show, using a steady-state analysis of a dynamical model, that the correlation between populations receiving the first and second routine dose also has a significant impact on the population immunity achieved by a specified combination of first and second dose coverage. If the second dose is administered to people independently of whether they had the first dose, high second-dose coverage improves the proportion of the population receiving at least one dose, and will have a large effect on population immunity. If the second dose is administered only to people who have had the first dose, high second-dose coverage reduces the rate of primary vaccine failure, but does not reach people who missed the first dose; this will therefore have a relatively small effect on population immunity. When doses are administered dependently, and assuming the first dose has higher coverage, increasing the coverage of the ...Continue Reading

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Citations

Oct 19, 2019·European Journal of Epidemiology·Emilie JavelleDidier Raoult
Aug 12, 2020·BMC Public Health·Basant Kumar PandaNiyi Awofeso
Aug 1, 2018·Vaccine·María Fernanda RivadeneiraSandra Costa Fuchs
Sep 25, 2019·The Lancet Infectious Diseases·Nicola Principi, Susanna Esposito
Nov 11, 2021·BMC Public Health·Susy Echeverria-LondonoKaty A M Gaythorpe

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