Correlation between molecular signals and bone bonding to titanium implants

Clinical Oral Implants Research
Marta MonjoStaale Petter Lyngstadaas

Abstract

A better understanding of the biological processes controlling osseointegration at the bone-to-implant interface is needed. The aim of this study was to examine which are the molecular and biochemical variables that are significantly related to osseointegration, using multiple regression analysis. Titanium coins were placed into the tibial cortical bone of New Zealand White rabbits and evaluated using pull-out test after 4 and 8 weeks of healing. Correlations between pull-out and several markers from tissue fluid (Lactate dehydrogenase [LDH] and Alkaline phosphatase [ALP] activities and total protein content) and peri-implant bone tissue (total protein, RNA and DNA content, implant area covered with bone and gene expression of osteoblast, osteoclast and inflammation markers) were used to assess the importance of these parameters in bone healing and in relation to implant performance. Our results showed a negative correlation between the content of DNA, RNA and total protein at the peri-implant bone tissue and the pull-out force, indicating that as bone matures and implant becomes more osseointegrated, the organic content of bone decreases. The negative correlation found between pull-out force and ALP activity pointed to a delay...Continue Reading

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Citations

Jan 1, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·M S WalterH J Haugen
Oct 26, 2013·Journal of Dental Research·I Nishimura
Jun 11, 2019·JOM : the Journal of the Minerals, Metals & Materials Society·Cate WisdomMalcolm L Snead
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Jul 8, 2019·ACS Biomaterials Science & Engineering·Sebastian GeißlerHanna Tiainen
May 30, 2020·ACS Biomaterials Science & Engineering·E Cate WisdomMalcolm L Snead

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