Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China

Genetics and Molecular Research : GMR
H SunX Q Huang

Abstract

Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hyper-tension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have different origins and are subjected to different environmental pressures. Therefore, additional studies are urgently needed to verify the GWAS findings across different populations. This study focused on the natriuretic peptide receptor C gene (NPR3), one of the hypertension-positive genes identified in a GWAS of an East Asian population. The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai (235 patients vs 215 controls) and 484 Chinese Mongolian (211 patients vs 273 controls) individuals. The positive SNP identified by GWAS analysis and three other tag SNPs representing the NPR3 linkage disequilibrium (LD) block regions were selected for genotyping. The results revealed that the rs1173766 polymorphism was associated with the occurrence of hypertension (χ(2) = 6.87, P = 0.0088), and that the T allele should be protective in the Dai ethnic group. Consider-ing a close LD block at t...Continue Reading

Citations

Sep 26, 2007·American Heart Journal·Tetsuro MatsunagaKinsuke Tsuda
May 13, 2017·Journal of Clinical Pharmacy and Therapeutics·D-B KuangX-P Chen
Feb 20, 2019·International Journal of Molecular Sciences·Speranza RubattuMassimo Volpe
Jun 1, 2017·Molecular Medicine Reports·Yihao WuDeye Yang

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