PMID: 6410141Aug 15, 1983Paper

Correlation between nortriptyline and debrisoquine hydroxylation in the human liver

Life Sciences
C von BahrK Nilsell

Abstract

The benzylic hydroxylation of nortriptyline (NT) and debrisoquine (D) by isolated human liver microsomes from eight subjects was studied. There was a strong correlation between the 10-hydroxylation of NT and the 4-hydroxylation of D (r = 0.96). The ability to hydroxylate D was also measured in vivo as the ratio between D and 4-OH-D in urine after oral administration of the drug to four subjects. This estimate of hydroxylation capacity agreed with the in vitro measurements. Liver microsomes from a subject defined as a poor in vivo oxidizer of D hydroxylated NT and D unusually slowly. Separation of microsomal proteins by SDS-gel electrophoresis indicated a relative lack of a cytochrome P-450 isozyme with a molecular weight of 54,500 in the liver from the poor oxidizer.

References

Sep 17, 1977·Lancet·A MahgoubR L Smith
Sep 1, 1979·European Journal of Clinical Pharmacology·M EichelbaumH J Dengler
Jul 15, 1985·Biochemical Pharmacology·C von BahrF Sjöqvist
Jun 1, 1980·Clinical Pharmacology and Therapeutics·C von BahrH Glaumann
May 1, 1982·British Journal of Clinical Pharmacology·G C KahnD S Davies
Jan 1, 1981·British Journal of Clinical Pharmacology·D S DaviesA R Boobis
Aug 1, 1981·Clinical Pharmacology and Therapeutics·B MellströmF Sjöqvist

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·P H Beaune, F P Guengerich
Feb 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E Spina, A P Caputi
Jan 1, 2011·Pharmacogenomics and Personalized Medicine·Yolande Lucire, Christopher Crotty
May 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C von BahrK Woodhouse
Jan 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R Boobis, D S Davies
Apr 1, 1985·British Journal of Clinical Pharmacology·J SäweA Rane
Aug 8, 1998·Clinical Pharmacology and Therapeutics·C von BahrJ Gabrielsson

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